Evidence map›Paper›PMID 38997144›Full record

ArticleeNeuro2024

A Vestibular Challenge Combined with Calcitonin Gene-Related Peptide (CGRP) Promotes Anxiety-Like Behaviors.

Shafaqat M Rahman, Catherine Hauser, Stefanie Faucher, Elana Fine, Anne E Luebke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Shafaqat M RahmanDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Catherine HauserDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Stefanie FaucherDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Elana FineDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627.
Anne E LuebkeDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14627 aluebke@ur.rochester.edu.ORCID https://orcid.org/0000-0001-5651-0278

Funding

Early auditory and imbalance measures in a mouse model of Alzheimer's Disease-SupplementR01DC017261 · NIDCD · UNIVERSITY OF ROCHESTER · PI LUEBKE, ANNE E · 2018 to 2022
$2.2M
NIDCD NIH HHS R01 DC017261
6 · The paper itself

Abstract

Motion-induced anxiety and agoraphobia are more frequent symptoms in patients with vestibular migraine (VM) than migraine without vertigo. The neuropeptide calcitonin gene-related peptide (CGRP) is a therapeutic target for migraine and VM, but the link between motion hypersensitivity, anxiety, and CGRP is relatively unexplored, especially in preclinical mouse models. To further examine this link, we tested the effects of systemic CGRP and off-vertical axis rotation (OVAR) on elevated plus maze (EPM) and rotarod performance in male and female C57BL/6J mice. Rotarod ability was assessed using two different dowel diameters: mouse dowel (

Indexed as

AnxietyCalcitonin Gene-Related PeptideMice, Inbred C57BLAnimalsBehavior, AnimalDisease Models, AnimalFemaleMaleMiceMigraine DisordersRotarod Performance TestVestibule, LabyrinthCalcitonin Gene-Related Peptideanxietycalcitonin gene-related peptide (CGRP)mouse modelsrotarod and elevated plus mazevestibularvestibular migraine

Identifiers

PMID38997144
PMCPMC11285090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.