Evidence map›Paper›PMID 38996860›Full record

ArticleAmerican heart journal2024

Race, hypertensive disorders of pregnancy and outcomes in peripartum cardiomyopathy.

Vincenzo B Polsinelli, Agnes Koczo, Amber E Johnson, Uri Elkayam, Leslie T Cooper, John Gorcsan, Joan Briller, James Fett, Dennis M McNamara, IPAC investigators

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vincenzo B PolsinelliUniversity of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address: vincenzo.polsinelli@cuanschutz.edu.
Agnes KoczoUniversity of Pittsburgh Medical Center, Pittsburgh, PA.
Amber E JohnsonUniversity of Chicago, Chicago, IL.
Uri ElkayamUniversity of Southern California, Los Angeles, CA.
Leslie T CooperMayo Clinic, Jacksonville, FL.
John GorcsanPenn State University, Hershey, PA.
Joan BrillerUniversity of Illinois, Chicago, IL.
James FettUniversity of Pittsburgh Medical Center, Pittsburgh, PA.
Dennis M McNamaraUniversity of Pittsburgh Medical Center, Pittsburgh, PA.
IPAC investigators

Funding

POSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2M
Immune Activation and Myocardial Recovery in Peripartum CardiomyopathyRC1HL102429 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCNAMARA, DENNIS M. · 2009 to 2010
$1000k
Mobile Health for Enhanced Hypertension Self-Management in Underserved Urban ResidentsK23HL165110 · NHLBI · UNIVERSITY OF CHICAGO · PI Amber Elaine Johnson · 2023 to 2026
$699k
NHLBI NIH HHS K23 HL165110NHLBI NIH HHS RC1 HL102429NHLBI NIH HHS T32 HL007822
6 · The paper itself

Abstract

backgroundBlack women with peripartum cardiomyopathy (PPCM) have a higher prevalence of hypertensive disorders of pregnancy (HDP) and worse clinical outcomes compared with non-Black women. We examined the impact of HDP on myocardial recovery in Black women with PPCM.

methodsA total of 100 women were enrolled into the Investigation in Pregnancy Associated Cardiomyopathy (IPAC) study. Left ventricular ejection fraction (LVEF) was assessed by echocardiography at entry, 6, and 12-months post-partum (PP). Women were followed for 12 months postpartum and outcomes including persistent cardiomyopathy (LVEF ≤35%), left ventricular assist device, (LVAD), cardiac transplantation, or death were examined in subsets based on race and the presence of HDP.

resultsBlack women with HDP were more likely to present earlier compared to Black women without HDP (days PP HDP: 34 ± 21 vs 54 ± 27 days, P = .03). There was no difference in LVEF at study entry for Black women based on HDP, but better recovery with HDP at 6 (HDP: 52 ± 11% vs no HDP: 40 ± 14%, P = .03) and 12-months (HDP:53 ± 10% vs no HDP:40 ± 16%, P = .02). At 12-months, Black women overall had a lower LVEF than non-Black women (P < .001), driven by less recovery in Black women without HDP compared to non-Black women (P < .001). In contrast, Black women with HDP had a similar LVEF at 12 months compared to non-Black women (P = .56).

conclusionsIn women with PPCM, poorer outcomes evident in Black women were driven by women without a history of HDP. In Black women, a history of HDP was associated with earlier presentation and recovery which was comparable to non-Black women.

Indexed as

Black or African AmericanCardiomyopathiesHypertension, Pregnancy-InducedPeripartum PeriodPregnancy Complications, CardiovascularStroke VolumeAdultEchocardiographyFemaleHeart-Assist DevicesHeart TransplantationHumansPregnancyVentricular Function, Left

Identifiers

PMID38996860
PMCPMC11437515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.