Evidence map›Paper›PMID 38996724›Full record

ArticleClinics (Sao Paulo, Brazil)2024

Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives.

Dongdong Zang, Xuemei Yang, Hao Wang, Zhenxing Li, Yanjun Ma, Jianxi Liu, Xi Mei, Shupeng Li, Jinxing Feng, Xin Shi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dongdong ZangDepartment of Neonatology, Shenzhen Children's Hospital, Shenzhen City, Guangdong Province, China.
Xuemei YangHealth Management Center, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen City, Guangdong Province, China.
Hao WangDepartment of Neurosurgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen City, Guangdong Province, China; Guangdong Engineering Technological Research Center for Nervous anatomy and Related Clinical Applications, Shenzhen City, Guangdong Province, China.
Zhenxing LiHealth Management Center, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen City, Guangdong Province, China.
Yanjun MaShenzhen Ruijian Biotechnology Co., LTD, Shenzhen City, Guangdong Province, China.
Jianxi LiuShenzhen Ruijian Biotechnology Co., LTD, Shenzhen City, Guangdong Province, China.
Xi MeiZhuhai Pengkun Biomedicine Technology Co. LTD, Zhuhai City, Guangdong Province, China.
Shupeng LiState Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen City, Guangdong Province, China.
Jinxing FengDepartment of Neonatology, Shenzhen Children's Hospital, Shenzhen City, Guangdong Province, China.
Xin ShiDepartment of Neurosurgery, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Centre, Shenzhen University, Shenzhen City, Guangdong Province, China.
Zhen TanDepartment of Neonatology, Shenzhen Children's Hospital, Shenzhen City, Guangdong Province, China; Health Management Center, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen City, Guangdong Province, China. Electronic address: tanzhen@szu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.

methodsFour HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds.

resultsIn the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.

conclusionThe results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short.

Indexed as

Antidepressive AgentsKetamineMotor ActivitySwimmingAnimalsBehavior, AnimalDepressionDisease Models, AnimalMaleMiceReproducibility of ResultsTime Factors6-hydroxynorketamineAntidepressive AgentsKetamineAntidepressantBehavioral Sensitization TestConditioned Place Preference TestForced Swimming TestHydroxynorketamine and its Derivatives

Identifiers

PMID38996724
PMCPMC11301192

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.