Evidence map›Paper›PMID 38996528›Full record

ArticleCell2024

Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching.

Chuanyun Xu, Zhuoran Li, Cheng Lyu, Yixin Hu, Colleen N McLaughlin, Kenneth Kin Lam Wong, Qijing Xie, David J Luginbuhl, Hongjie Li, Namrata D Udeshi and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. The Trajectory Statistics of Biological Exploratory Dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  3. eLife · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Chuanyun XuDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
Zhuoran LiDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
Cheng LyuDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Yixin HuDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
Colleen N McLaughlinDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Kenneth Kin Lam WongDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Qijing XieDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Neurosciences Graduate Program, Stanford University, Stanford, CA 94305, USA.
David J LuginbuhlDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Hongjie LiDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Namrata D UdeshiThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tanya SvinkinaThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
D R ManiThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Shuo HanDepartments of Genetics, Biology, and Chemistry, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305, USA.
Tongchao LiDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Yang LiDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
Ricardo GuajardoDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Alice Y TingDepartments of Genetics, Biology, and Chemistry, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305, USA.
Steven A CarrThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jiefu LiDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA. Electronic address: lij6@janelia.hhmi.org.
Liqun LuoDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: lluo@stanford.edu.

Funding

Mapping protein communication between organs in homeostasis and diseaseR01DK121409 · NIDDK · HARVARD MEDICAL SCHOOL · PI CARR, STEVEN A, MCMAHON, ANDREW P. · 2018 to 2022
$8.3M
Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
Howard Hughes Medical InstituteNIDCD NIH HHS R01 DC005982NIDDK NIH HHS R01 DK121409
6 · The paper itself

Abstract

In developing brains, axons exhibit remarkable precision in selecting synaptic partners among many non-partner cells. Evolutionarily conserved teneurins are transmembrane proteins that instruct synaptic partner matching. However, how intracellular signaling pathways execute teneurins' functions is unclear. Here, we use in situ proximity labeling to obtain the intracellular interactome of a teneurin (Ten-m) in the Drosophila brain. Genetic interaction studies using quantitative partner matching assays in both olfactory receptor neurons (ORNs) and projection neurons (PNs) reveal a common pathway: Ten-m binds to and negatively regulates a RhoGAP, thus activating the Rac1 small GTPases to promote synaptic partner matching. Developmental analyses with single-axon resolution identify the cellular mechanism of synaptic partner matching: Ten-m signaling promotes local F-actin levels and stabilizes ORN axon branches that contact partner PN dendrites. Combining spatial proteomics and high-resolution phenotypic analyses, this study advanced our understanding of both cellular and molecular mechanisms of synaptic partner matching.

Indexed as

AxonsDrosophila melanogasterDrosophila ProteinsNerve Tissue ProteinsOlfactory Receptor NeuronsSignal TransductionSynapsesActinsAnimalsBrainDendritesGTPase-Activating Proteinsrac1 GTP-Binding Proteinrac GTP-Binding ProteinsTenascinActinsDrosophila ProteinsGTPase-Activating ProteinsNerve Tissue Proteinsrac1 GTP-Binding ProteinRac1 protein, Drosophilarac GTP-Binding ProteinsTenascinteneurin-1branch stabilizationDrosophilahomophilic attractionolfactory circuitolfactory receptor neuronsprojection neuronsRhoGAPRho GTPasessynaptic partner matchingteneurin

Identifiers

PMID38996528
PMCPMC11833509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.