Evidence map›Paper›PMID 38996073›Full record

ArticleCell reports2024

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

Morven Chin, Pascal S Kaeser

Abstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Morven ChinDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Pascal S KaeserDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: kaeser@hms.harvard.edu.

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Molecular Dissection of Active Zone Functions in Neurotransmitter ReleaseR01NS083898 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2014 to 2026
$5.9M
Roles for dopamine signaling modes in striatal circuit modulation and behaviorR01DA058777 · NIDA · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser, Naoshige Uchida · 2024 to 2026
$2.0M
Dissecting the Forward Trafficking of Presynaptic Voltage Gated Calcium ChannelsF31NS127399 · NINDS · HARVARD MEDICAL SCHOOL · PI CHIN, MORVEN · 2023 to 2025
$90k
NICHD NIH HHS P50 HD105351NIDA NIH HHS R01 DA058777NINDS NIH HHS F31 NS127399NINDS NIH HHS R01 NS083898
6 · The paper itself

Abstract

To achieve the functional polarization that underlies brain computation, neurons sort protein material into distinct compartments. Ion channel composition, for example, differs between axons and dendrites, but the molecular determinants for their polarized trafficking remain obscure. Here, we identify mechanisms that target voltage-gated Ca

Indexed as

HippocampusAnimalsCalcium ChannelsCalcium Channels, L-TypeCalcium Channels, N-TypeExocytosisHEK293 CellsHumansMiceNeuronsRatsSynaptic VesiclesCalcium ChannelsCalcium Channels, L-TypeCalcium Channels, N-Typeactive zoneaxonCP: Cell biologyCP: NeuroscienceEF handneuronal polaritypresynapticprotein traffickingsynapsesynaptic vesiclevoltage-gated Ca2+ channel

Identifiers

PMID38996073
PMCPMC11441329

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.