ArticleCell reports2024
Astroglial networks control visual responses of superior collicular neurons and sensory-motor behavior.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The multiple scales of astrocytic functional units.Nature neuroscience · 2026Review
- Interneuron and glial mechanisms underlying V1 orientation map dynamics.IBRO neuroscience reports · 2026Article
- Protocol for recording visual maps in the mouse superior colliculus and visual cortex with intrinsic optical imaging.STAR protocols · 2026Article
- Gap junction-mediated signaling coordinates Rhodopsin coupling for Drosophila color vision.Biology open · 2026Article
- The Astroglia Syncytial Theory of Consciousness.International journal of molecular sciences · 2025Review
- Rethinking Sensory Information Processing: The Essential Role of Astrocytes.Journal of neurochemistry · 2025Review
- The Duality of Astrocyte Neuromodulation: Astrocytes Sense Neuromodulators and Are Neuromodulators.Journal of neurochemistry · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Astroglial networks closely interact with neuronal populations, but their functional contribution to neuronal representation of sensory information remains unexplored. The superior colliculus (SC) integrates multi-sensory information by generating distinct spatial patterns of neuronal functional responses to specific sensory stimulation. Here, we report that astrocytes from the mouse SC form extensive networks in the retinorecipient layer compared to visual cortex. This strong astroglial connectivity relies on high expression of gap-junction proteins. Genetic disruption of this connectivity functionally impairs SC retinotopic and orientation preference responses. These alterations are region specific, absent in primary visual cortex, and associated at the circuit level with a specific impairment of collicular neurons synaptic transmission. This has implications for SC-related visually induced innate behavior, as disrupting astroglial networks impairs light-evoked temporary arrest. Our results indicate that astroglial networks shape synaptic circuit activity underlying SC functional visual responses and play a crucial role in integrating visual cues to drive sensory-motor behavior.
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Registered trials
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