Evidence map›Paper›PMID 38996013›Full record

ArticleScience advances2024

Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina.

Nguyet Le, Trieu-Duc Vu, Isabella Palazzo, Ritvik Pulya, Yehna Kim, Seth Blackshaw, Thanh Hoang

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  18. Development of Retinal Astroglia.Annual review of vision science · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nguyet LeDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1412-0500
Trieu-Duc VuDepartment of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, MI 48105.ORCID 0000-0001-6770-6727
Isabella PalazzoDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-5752-0969
Ritvik PulyaDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7639-1640
Yehna KimDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Seth BlackshawDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1338-8476
Thanh HoangDepartment of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, MI 48105.ORCID 0000-0002-7666-3842

Funding

Identification of gene regulatory networks that control proliferative and neurogenic competence in mammalian Müller gliaR01EY031685 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2020 to 2023
$2.0M
Identification of gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller gliaR01EY036173 · NEI · JOHNS HOPKINS UNIVERSITY · PI Seth Blackshaw · 2024 to 2026
$2.0M
NEI NIH HHS R01 EY031685NEI NIH HHS R01 EY036173
6 · The paper itself

Abstract

Generation of neurons through direct reprogramming has emerged as a promising therapeutic approach for treating neurodegenerative diseases. In this study, we present an efficient method for reprogramming retinal glial cells into neurons. By suppressing Notch signaling by disrupting either

Indexed as

Cellular ReprogrammingEpendymoglial CellsNeurogliaNeuronsNFI Transcription FactorsReceptors, NotchRetinaSignal TransductionAnimalsCell ProliferationImmunoglobulin J Recombination Signal Sequence-Binding ProteinMiceNeurogenesisYAP-Signaling ProteinsImmunoglobulin J Recombination Signal Sequence-Binding ProteinNfia protein, mouseNFI Transcription FactorsRbpj protein, mouseReceptors, NotchYap1 protein, mouseYAP-Signaling Proteins

Identifiers

PMID38996013
PMCPMC11244444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.