Evidence map›Paper›PMID 38996012›Full record

ArticleScience advances2024

DNA methylation enables recurrent endogenization of giant viruses in an animal relative.

Luke A Sarre, Iana V Kim, Vladimir Ovchinnikov, Marine Olivetta, Hiroshi Suga, Omaya Dudin, Arnau Sebé-Pedrós, Alex de Mendoza

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Allele-specific methylation ofScience advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luke A SarreSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.ORCID 0000-0002-5046-065X
Iana V KimCRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0003-4997-1871
Vladimir OvchinnikovSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.ORCID 0000-0003-0350-8478
Marine OlivettaSwiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID 0000-0002-9451-0663
Hiroshi SugaFaculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara, Japan.ORCID 0000-0003-1795-2174
Omaya DudinSwiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID 0000-0002-6673-3149
Arnau Sebé-PedrósCRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0002-9896-9746
Alex de MendozaSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.ORCID 0000-0002-6441-6529

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Methylcytosine (5mC) is a widespread silencing mechanism that controls genomic parasites. In eukaryotes, 5mC has gained complex roles in gene regulation beyond parasite control, yet 5mC has also been lost in many lineages. The causes for 5mC retention and its genomic consequences are still poorly understood. Here, we show that the protist closely related to animals

Indexed as

DNA MethylationGiant Viruses5-MethylcytosineAnimalsDNA Transposable ElementsDNA, Viral5-MethylcytosineDNA Transposable ElementsDNA, Viral

Identifiers

PMID38996012
PMCPMC11244446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.