ArticleProceedings of the National Academy of Sciences of the United States of America2024
Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like neurodegeneration.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed.
- The neuroimmune network in Alzheimer's and Parkinson's diseases: from mechanistic insights to biomarker-guided immunotherapies and clinical translation.Inflammopharmacology · 2026Review
- Meningeal and infiltrating T-cells are associated with repetitive head trauma and tau-mediated neurodegeneration in chronic traumatic encephalopathy.Acta neuropathologica communications · 2026Article
- Microglia-Astrocyte Cooperation and Peripheral T Cells in Alzheimer's Disease: State-of-the-Art and Treatment Perspectives.International journal of molecular sciences · 2026Review
- New Perspective: Bench to Bedside Evidence of the Role of CD8+ T Cells in Alzheimer's Disease.Immunity, inflammation and disease · 2026Review
- Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.Cell systems · 2026Article
- RhCMV expands CCR5+ memory T cells and promotes SIV reservoir seeding in the gut mucosa.JCI insight · 2026Article
- Association between Alzheimer's disease and MHC-I antigen processing and presentation pathway: a narrative review.Frontiers in immunology · 2026Review
- Targeting neuroimmune interactions: the therapeutic potential of kaempferol in immune-related central nervous system disorders.Frontiers in immunology · 2026Review
- Blood-brain barrier dysfunction and peripheral immune activation in Alzheimer's disease: an inflammation-centered review.Frontiers in immunology · 2026Review
- Adaptive Immunity and Alzheimer's Disease: Dual Roles in Neurodegeneration and Neuroprotection with Therapeutic Implications.Biomolecules & therapeutics · 2026Review
- Spilling the T: T cells in tauopathy mechanisms, disease progression, and therapeutic horizons.Molecular neurodegeneration advances · 2026Review
- Systemic inflammation as a central player in the initiation and development of Alzheimer's disease.Immunity & ageing : I & A · 2025Review
- Fingolimod ameliorates amyloid deposition and neurodegeneration in APP/PS1 mouse model of Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025Article
- Aging reshapes the adaptive immune system from healer to saboteur.Nature aging · 2025Review
- Antigen-Specifically Activated CD8+ and Double-Negative T Cells Accumulate in the Brain of Alzheimer's Disease Mice.Aging and disease · 2025Article
- Identification of therapeutic targets for Alzheimer's Disease Treatment using bioinformatics and machine learning.Scientific reports · 2025Article
- Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases.Frontiers in immunology · 2025Review
- Review
- Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone.The Biochemical journal · 2024Article
- Central role of brain regulatory T cells in the inflammatory cascade in Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
21 authors.
Akanksha Panwar *Department Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Altan Rentsendorj *Department Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.ORCID 0009-0001-4322-8107
Michelle Jhun *Department Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Robert M CohenDepartment Psychiatry & Behavioral Sciences and Neuroscience Program, Graduate Division of Biological and Biomedical Sciences (GDBBS), Emory University, Atlanta, GA 30322.
Ryan CordnerDepartment Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Nicole GullDepartment Biomedical & Translational Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048.ORCID 0000-0002-1956-5648
Robert N PechnickDepartment of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific Western University of Health Sciences, Pomona, CA 91766.
Gretchen DuvallDepartment Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Armen MardirosDepartment Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
David GolchianDepartment Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Hannah SchubloomDepartment Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Lee-Way JinDepartment Medical Pathology and Laboratory Medicine, Laboratory Medicine, Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute, University of California, Davis, Sacramento, CA 95817.
Debby Van DamDepartment of Biomedical Sciences, Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp 2610, Belgium.ORCID 0000-0003-4739-6076
Yannick VermeirenDepartment of Biomedical Sciences, Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp 2610, Belgium.ORCID 0000-0002-2091-5326
Hans De ReuFaculty of Medicine and Health Sciences, Vaccine and Infectious Disease Institute, Laboratory of Experimental Hematology, University of Antwerp, Antwerp 2610, Belgium.ORCID 0000-0003-0120-3160
Peter Paul De DeynDepartment of Biomedical Sciences, Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp 2610, Belgium.
Jevgenij A RaskatovDepartment of Chemistry & Biochemistry, University of California, Santa Cruz, CA 95064.
Keith L BlackDepartment Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.ORCID 0000-0002-0546-4934
Dwain K IrvinDepartment Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.ORCID 0009-0008-8870-928X
Brian A WilliamsTranscriptome Function and Technology Program, Department of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Christopher J WheelerDepartment Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.ORCID 0000-0003-0618-8748
Funding
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3MUC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2MEGFR activity in T cell-influenced glioma invasiveness & chemosensitivityR21NS054162 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI WHEELER, CHRISTOPHER JAY · 2006 to 2007
$380kThe Role of CD8+ Tcells in a Rat Model of Alzheimer's DiseaseR21AG033394 · NIA · CEDARS-SINAI MEDICAL CENTER · PI COHEN, ROBERT MARTIN · 2009 to 2010
$365kCedars-Sinai Medical Center Biobehavioral Core N/AHHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21NSO54162HHS | NIH | National Institute on Aging (NIA) P30AG10129HHS | NIH | National Institute on Aging (NIA) R21AG033394Joseph Drown Foundation (The Joseph Drown Foundation) N/AMaxine Dunitz Neurosurgical Institute N/ANIA NIH HHS P30 AG010129NIA NIH HHS P30 AG072972NIA NIH HHS R21 AG033394NINDS NIH HHS R21 NS054162
Abstract
Cerebral (Aβ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer's disease (AD), yet are insufficient to confer complete AD-like neurodegeneration experimentally. Factors acting upstream of Aβ/pTau in AD remain unknown, but their identification could enable earlier diagnosis and more effective treatments. T cell abnormalities are emerging AD hallmarks, and CD8 T cells were recently found to mediate neurodegeneration downstream of tangle deposition in hereditary neurodegeneration models. The precise impact of T cells downstream of Aβ/pTau, however, appears to vary depending on the animal model. Our prior work suggested that antigen-specific memory CD8 T ("
Indexed as
Alzheimer DiseaseCD8-Positive T-LymphocytesDisease Models, AnimalAgingAmyloid beta-PeptidesAnimalsBrainFemaleHumansImmunologic MemoryInterferon-gammaMaleMemory T CellsMiceMice, TransgenicPerforinAmyloid beta-PeptidesInterferon-gammaPerforinAlzheimer’s diseasebiomarkermouse modelneuroscienceT cell
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