Evidence map›Paper›PMID 38995807›Full record

ArticleNeuroRehabilitation2024

Testosterone and neurobehavioral outcomes in special operations forces military with multiple mild traumatic brain injury.

Nathan Barnett, Milica Ljubic, Joyce Chung, Allison Capizzi

Abstract read
In one paragraph

Article in NeuroRehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nathan BarnettPolytrauma System of Care, VA Palo Alto Healthcare System, Palo Alto, CA, USA.
Milica LjubicPolytrauma System of Care, VA Palo Alto Healthcare System, Palo Alto, CA, USA.
Joyce ChungPolytrauma System of Care, VA Palo Alto Healthcare System, Palo Alto, CA, USA.
Allison CapizziPolytrauma System of Care, VA Palo Alto Healthcare System, Palo Alto, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundU.S. Special Operations Forces (SOF) are at increased risk of multiple mild traumatic brain injury (mmTBI). Testosterone was prescribed for several participants in a VA program designed to address sequelae of mmTBI for SOF.

objectiveTo determine testosterone prevalence in the Palo Alto VA Intensive Evaluation and Treatment Program (IETP) and observe for association between testosterone and neurobehavioral outcomes.

methodsA retrospective cohort study included patients in the Palo Alto VA IETP. Sociodemographic data, testosterone blood levels, and neurobehavioral outcomes were collected from medical records.

results55 IETP participants were included: six were testosterone users; the rest were classified as non-users. Testosterone use in this population is 11%, higher than reported national averages in the U.S. Of the 6 testosterone users, 2 (33%) had a formal diagnosis of hypogonadism prior to initiation of testosterone. Neurobehavioral outcome scores between testosterone users and non-users failed to show statistically significant differences, except for the PROMIS pain score, which was higher in the testosterone user population.

conclusionThe current study did not find an association between mmTBI, testosterone use, or testosterone level and neurobehavioral outcomes. This study highlights a need to further examine the relationship between hypogonadism, mmTBI, SOF culture around testosterone, and the effects of testosterone use in this population.

Indexed as

Brain ConcussionMilitary PersonnelTestosteroneAdultFemaleHumansHypogonadismMaleMiddle AgedRetrospective StudiesYoung AdultTestosteronehypogonadismmultiple mild traumatic brain injuryneuroendocrine dysfunctionspecial operations forcesTBItestosteroneTraumatic brain injury

Identifiers

PMID38995807
PMCPMC11612980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.