Evidence map›Paper›PMID 38995680›Full record

ArticleeLife2024

Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy.

Boglarka Zambo, Evelina Edelweiss, Bastien Morlet, Luc Negroni, Matyas Pajkos, Zsuzsanna Dosztanyi, Soren Ostergaard, Gilles Trave, Jocelyn Laporte, Gergo Gogl

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. State-of-the-Art and Future Directions in Structural Proteomics.Molecular & cellular proteomics : MCP · 2025
    Review
  5. Role of Dyadic Proteins in Proper Heart Function and Disease.International journal of molecular sciences · 2025
    Review
  6. BIN1 reduction amelioratesProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Dynamics of membrane tubulation coupled with fission by a two-component module.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Boglarka ZamboEquipe Labellisee Ligue 2015, Departement de Biologie Structurale Integrative, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Universite de Strasbourg, Illkirch, France.
Evelina EdelweissInstitut de Genetique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, Illkirch, France.
Bastien MorletInstitut de Genetique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, Illkirch, France.
Luc NegroniInstitut de Genetique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, Illkirch, France.
Matyas PajkosDepartment of Biochemistry, ELTE Eötvös Loránd University, Budapest, Hungary.
Zsuzsanna DosztanyiDepartment of Biochemistry, ELTE Eötvös Loránd University, Budapest, Hungary.
Soren OstergaardNovo Nordisk A/S, Global Research Technologies, Novo Nordisk Research Park, Maaloev, Denmark.
Gilles TraveEquipe Labellisee Ligue 2015, Departement de Biologie Structurale Integrative, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Universite de Strasbourg, Illkirch, France.
Jocelyn LaporteInstitut de Genetique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, Illkirch, France.ORCID https://orcid.org/0000-0001-8256-5862
Gergo GoglEquipe Labellisee Ligue 2015, Departement de Biologie Structurale Integrative, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Universite de Strasbourg, Illkirch, France.ORCID https://orcid.org/0000-0002-8597-3711

Funding

AFM-Téléthon 23933Agence Nationale de la Recherche ANR-18-CE92-0017Agence Nationale de la Recherche ANR-22-CE11-0026Agence Nationale de la Recherche ANR-22-CE44-0018Inserm CRCN starting packageInstitut de génétique et de biologie moléculaire et cellulaire post doc grantLigue Contre le Cancer 2015OTKA K139284
6 · The paper itself

Abstract

Truncation of the protein-protein interaction SH3 domain of the membrane remodeling Bridging Integrator 1 (BIN1, Amphiphysin 2) protein leads to centronuclear myopathy. Here, we assessed the impact of a set of naturally observed, previously uncharacterized BIN1 SH3 domain variants using conventional

Indexed as

Adaptor Proteins, Signal TransducingMyopathies, Structural, CongenitalNuclear Proteinssrc Homology DomainsTumor Suppressor ProteinsDynamin IIHumansMutationProtein BindingAdaptor Proteins, Signal TransducingBIN1 protein, humanDynamin IINuclear ProteinsTumor Suppressor ProteinsBIN1biochemistrybiophysicschemical biologyhumaninteractomicsmyopathySH3 domain

Identifiers

PMID38995680
PMCPMC11245310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.