Evidence map›Paper›PMID 38995621›Full record

ArticleJournal of natural products2024

Chemoreactive 2,5-Diketopiperazines from a

Quan T Khong, Emily A Smith, Karen L Wendt, Masoumeh Dalilian, Ekaterina I Goncharova, Isaac Brownell, Robert H Cichewicz, Curtis J Henrich, John A Beutler, Barry R O'Keefe and 1 more

Abstract read
In one paragraph

Article in Journal of natural products, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Quan T KhongMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.
Emily A SmithMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.
Karen L WendtNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
Masoumeh DalilianMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.
Ekaterina I GoncharovaMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.
Isaac BrownellDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, United States.
Robert H CichewiczNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.ORCID 0000-0003-0744-4117
Curtis J HenrichMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.
John A BeutlerMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0002-4646-1924
Barry R O'KeefeMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0003-0772-4856
Lin DuMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0001-8751-4482

Funding

Building Libraries with Chemical Diversity for ScreeningZIABC011469 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
Development of Natural Product Leads as Anticancer TherapeuticsZIABC011470 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
Molecular pathogenesis and therapy innovation for Merkel cell carcinomaZIAAR041222 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI BROWNELL, ISAAC · 2022 to 2025
$4.0M
Sourcing Bioactive Secondary Metabolites from Great Lakes FungiR01GM107490 · NIGMS · UNIVERSITY OF OKLAHOMA · PI CICHEWICZ, ROBERT HENRY, MOOBERRY, SUSAN L · 2014 to 2017
$2.3M
Intramural NIH HHS ZIA AR041222NIGMS NIH HHS R01 GM107490
6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous cancer. Two new prenylated indole 2,5-diketopiperazine alkaloids, brevianamides E1 (

Indexed as

DiketopiperazinesPenicilliumAntineoplastic AgentsDrug Screening Assays, AntitumorHumansMolecular StructureAntineoplastic AgentsDiketopiperazines

Identifiers

PMID38995621
PMCPMC12182282

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.