Evidence map›Paper›PMID 38995611›Full record

ReviewJournal of cardiovascular translational research2024

Comprehensive Quality Analysis of Conventional and Novel Biomarkers in Diagnosing and Predicting Prognosis of Coronary Artery Disease, Acute Coronary Syndrome, and Heart Failure, a Comprehensive Literature Review.

Muhammad Abubakar, Umema Irfan, Ahmad Abdelkhalek, Izzah Javed, Muhammad Imran Khokhar, Fraz Shakil, Saud Raza, Siffat Saima Salim, Muhammad Mahran Altaf, Rizwan Habib and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Elevated ASGR1 as a Potential Diagnostic Biomarker for Coronary Artery Disease and Predictor of Adverse Outcomes in Hypertensive Patients.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Muhammad AbubakarDepartment of Internal Medicine, Ameer-Ud-Din Medical College, 6 Birdwood Road, Jinnah Town, Lahore, 54000, Punjab, Pakistan. Muhammadabubakar2053@hotmail.com.ORCID 0000-0002-3561-8631
Umema IrfanDepartment of Internal Medicine, Deccan College of Medical Sciences, Hyderabad, India.
Ahmad AbdelkhalekDepartment of Internal Medicine, Zhejiang University, Zhejiang, China.
Izzah JavedDepartment of Internal Medicine, Ameer-Ud-Din Medical College, 6 Birdwood Road, Jinnah Town, Lahore, 54000, Punjab, Pakistan.
Muhammad Imran KhokharDepartment of Surgery, Gujranwala Medical College, Gujranwala, Pakistan.
Fraz ShakilDepartment of Emergency Medicine, Mayo Hospital, Lahore, Pakistan.
Saud RazaDepartment of Anesthesia, Social Security Teaching Hospital, Lahore, Punjab, Pakistan.
Siffat Saima SalimDepartment of Surgery, Holy Family Red Crescent Medical College Hospital, Dhaka, Bangladesh.
Muhammad Mahran AltafDepartment of Internal Medicine, Ameer-Ud-Din Medical College, 6 Birdwood Road, Jinnah Town, Lahore, 54000, Punjab, Pakistan.
Rizwan HabibDepartment of Internal Medicine and Emergency, Indus Hospital, Lahore, Pakistan.
Simra AhmedDepartment of Internal Medicine, Ziauddin Medical College, Karachi, Pakistan.
Farea AhmedDepartment of Internal Medicine, Ziauddin Medical College, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease (CAD), acute coronary syndrome (ACS), and heart failure (HF) are major global health issues with high morbidity and mortality rates. Biomarkers like cardiac troponins (cTn) and natriuretic peptides (NPs) are crucial tools in cardiology, but numerous new biomarkers have emerged, proving increasingly valuable in CAD/ACS. These biomarkers are classified based on their mechanisms, such as fibrosis, metabolism, inflammation, and congestion. The integration of established and emerging biomarkers into clinical practice is an ongoing process, and recognizing their strengths and limitations is crucial for their accurate interpretation, incorporation into clinical settings, and improved management of CVD patients. We explored established biomarkers like cTn, NPs, and CRP, alongside newer biomarkers such as Apo-A1, IL-17E, IgA, Gal-3, sST2, GDF-15, MPO, H-FABP, Lp-PLA2, and ncRNAs; provided evidence of their utility in CAD/ACS diagnosis and prognosis; and empowered clinicians to confidently integrate these biomarkers into clinical practice based on solid evidence.

Indexed as

Acute Coronary SyndromeBiomarkersCoronary Artery DiseaseHeart FailurePredictive Value of TestsHumansPrognosisReproducibility of ResultsRisk AssessmentBiomarkersAcute coronary syndromeCongestionCoronary artery diseaseGalectin-3GDF-15Heart failureMyeloperoxidaseNon-coding RNAsPrognostic biomarkerssST2

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.