Evidence map›Paper›PMID 38995391›Full record

ArticleLung2024

Transcriptomic Expression of T2-Inflammation Genes in Peripheral Blood Mononuclear Cells and Longitudinal Clinical Outcomes in Asthma: Insights from the COREA Study.

Duong Duc Pham, Eunsoon Shin, Jong Eun Lee, Ji-Hyang Lee, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Sungho Won, Tae-Bum Kim

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Duong Duc PhamDivision of Allergy and Clinical Immunology, Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Eunsoon ShinDNA Link, Seoul, South Korea.
Jong Eun LeeDNA Link, Seoul, South Korea.
Ji-Hyang LeeDivision of Allergy and Clinical Immunology, Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Woo-Jung SongDivision of Allergy and Clinical Immunology, Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Hyouk-Soo KwonDivision of Allergy and Clinical Immunology, Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
You Sook ChoDivision of Allergy and Clinical Immunology, Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Sungho WonDepartment of Public Health Sciences, Graduate School of Public Health, Interdisciplinary Program of Bioinformatics, College of Natural Science, Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Tae-Bum KimDivision of Allergy and Clinical Immunology, Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Korea. tbkim@amc.seoul.kr.

Funding

National Research Foundation of Korea 2019M3E5D3073365
6 · The paper itself

Abstract

backgroundGene expression can provide distinct information compared to clinical biomarkers in the context of longitudinal clinical outcomes in asthma patients.

objectiveThis study examined the association between the gene expression levels of upstream (IL-25, IL-33, and TSLP) and downstream cytokines (IL-5, IL-4, and IL-13) in the T2 inflammatory pathway with a 12-month follow-up of exacerbation, lung function, and steroid use.

methodsTranscriptomic sequencing analysis was performed on peripheral blood mononuclear cells from 279 adult asthmatics. Survival analysis and linear mixed-effect models were used to investigate potential differences between the high-level and low-level gene expression groups and the clinical outcomes. Analysis was performed separately for the upstream, downstream, and all 6 cytokines.

resultsIn general, T2 inflammatory cytokine gene expression showed a weak correlation with blood eosinophil counts (all r < 0.1) and clinical outcomes. Among moderate-to-severe eosinophilic asthma (MSEA) patients, individuals with elevated levels of downstream cytokines were at increased risk of time-to-first exacerbation (p = 0.044) and a greater increase of inhaled corticosteroid use over time (p = 0.002) compared to those with lower gene expression. There was no association between baseline T2 inflammatory cytokine gene expression and the longitudinal changes in lung function over time among MSEA patients.

conclusionThese findings suggest that, among MSEA patients, the gene expression levels of downstream cytokines in the T2 inflammatory pathway may serve as indicators for endotyping asthma.

Indexed as

AsthmaCytokinesInterleukin-13Interleukin-4Leukocytes, MononuclearTranscriptomeAdrenal Cortex HormonesAdultDisease ProgressionEosinophilsFemaleGene Expression ProfilingHumansInterleukin-17Interleukin-33Interleukin-5Adrenal Cortex HormonesCytokinesIL25 protein, humanIL33 protein, humanIL4 protein, humanIL5 protein, humanInterleukin-13Interleukin-17Interleukin-33Interleukin-4Interleukin-5Thymic Stromal LymphopoietinEndotypeGene expressionT2 inflammatory cytokines

Identifiers

PMID38995391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.