Evidence map›Paper›PMID 38995327›Full record

Observational studySleep & breathing = Schlaf & Atmung2024

Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods.

Andira I Anwar, Sean Byrne, Akanksha Sharma, Scott Sands, Andrew Wellman, Nancy S Redeker, Henry Yaggi, Andrey V Zinchuk

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05067088 (Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05067088 completednot on this map

Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness: NICEPAP Study Prospective Cohort

TypeobservationalSponsorYale UniversityRan2022 to 2026Enrolled262ConditionsObstructive Sleep ApneaArmsCPAP (all patients receive CPAP as part of routine clinical care)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andira I AnwarDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut, CT, 06443, USA.
Sean ByrneDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut, CT, 06443, USA.
Akanksha SharmaUniversity of Pittsburgh Medical Center Mercy, Pittsburgh, PA, USA.
Scott SandsDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Andrew WellmanDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nancy S RedekerUniversity of Connecticut School of Nursing, Connecticut, USA.
Henry YaggiDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut, CT, 06443, USA.
Andrey V ZinchukDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut, CT, 06443, USA. andrey.zinchuk@yale.edu.ORCID 0000-0003-0488-9778

Funding

Validation of a Phenotype Model to Predict Response to Alternative OSA TreatmentsR01HL102321 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WELLMAN, DAVID ANDREW · 2011 to 2025
$7.3M
Novel physiologiC prEdictors of Positive Airway Pressure effectiveness: NICE-PAP study.K23HL159259 · NHLBI · YALE UNIVERSITY · PI ZINCHUK, ANDREY · 2021 to 2025
$843k
Mentoring in Sleep Research and Sleep Interventions in Heart Disease, and StrokeK24HL132093 · NHLBI · YALE UNIVERSITY · PI YAGGI, HENRY KLAR · 2016 to 2020
$336k
NHLBI NIH HHS HL102321NHLBI NIH HHS HL132093NHLBI NIH HHS HL159259NHLBI NIH HHS K23 HL159259NHLBI NIH HHS L30 HL143623NHLBI NIH HHS R01 HL102321
6 · The paper itself

Abstract

purposeContinuous positive airway pressure (CPAP) is the primary therapy for obstructive sleep apnea (OSA); however the effectiveness of CPAP remains suboptimal. We describe the Novel PhysIologiC prEdictors of Positive Airway Pressure Effectiveness (NICEPAP) study. Its purpose is to determine whether physiological traits of OSA contribute to CPAP effectiveness.

methodsNICEPAP (NCT05067088) is a prospective, observational cohort study conducted at an academic sleep center. Adults newly diagnosed with OSA (n = 267) are assessed for OSA traits of loop gain, arousal threshold, pharyngeal collapsibility, and muscle compensation from baseline polysomnography. We perform a comprehensive assessment of covariates relevant to CPAP adherence, efficacy, and patient-centered outcomes. Participants are followed for 12 months. Primary outcomes include (1) CPAP adherence (hours/night), (2) CPAP efficacy (apneas-hypopneas/hour), and (3) quality of life at six months measured by objective CPAP data and Functional Outcomes of Sleep Questionnaire. Secondary outcomes include sleep quality, sleepiness, insomnia, and neurocognitive function.

resultsData on covariates, including demographics, sleep symptoms, medical history, medications, sleep quality, OSA and treatment self-efficacy, decisional balance, and socio-economic and social and partner support, are collected using validated instruments. The analysis for primary outcomes includes a generalized linear mixed model for an outcome (e.g., CPAP adherence) with OSA traits as exposures followed by the addition of relevant covariates.

conclusionThe findings of the NICEPAP study will inform research aimed to enhance CPAP effectiveness. Understanding the role of physiological OSA traits in CPAP effectiveness is a crucial step toward a precision medicine approach to OSA.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveAdultCohort StudiesFemaleHumansMaleMiddle AgedPatient CompliancePolysomnographyProspective StudiesTreatment OutcomeAdherenceContinuous positive airway pressureEffectivenessObstructive sleep apneaPhysiological traits

Identifiers

PMID38995327
PMCPMC12301967

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.