Evidence map›Paper›PMID 38995212›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Glucocorticoids impair T lymphopoiesis after myocardial infarction.

Danielle X Shane, Daria M Konovalova, Harishkumar Rajendran, Sarah Y Yuan, Yonggang Ma

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. CD8FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Danielle X ShaneDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Daria M KonovalovaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Harishkumar RajendranDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Sarah Y YuanDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Yonggang MaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.ORCID 0000-0003-1711-0639

Funding

Vascular Barrier Leakage in InflammationR35HL150732 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2020 to 2026
$6.2M
T Lymphopenia in Ischemic Heart FailureR01HL164446 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Yonggang Ma · 2022 to 2026
$2.0M
Endothelial glycocalyx shedding in septic injuryR01GM142110 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI WU, MACK H, YUAN, SARAH Y · 2022 to 2025
$1.9M
NHLBI NIH HHS R01 HL164446NHLBI NIH HHS R35 HL150732NIGMS NIH HHS R01 GM142110
6 · The paper itself

Abstract

The thymus, where T lymphocytes develop and mature, is sensitive to insults such as tissue ischemia or injury. The insults can cause thymic atrophy and compromise T-cell development, potentially impairing adaptive immunity. The objective of this study was to investigate whether myocardial infarction (MI) induces thymic injury to impair T lymphopoiesis and to uncover the underlying mechanisms. When compared with sham controls, MI mice at

Indexed as

AdrenalectomyApoptosisLymphopoiesisMice, Inbred C57BLMyocardial InfarctionThymus GlandAnimalsCorticosteroneDisease Models, AnimalEosinophilsGlucocorticoidsMaleMiceSpleenThymocytesT-LymphocytesCorticosteroneGlucocorticoidsglucocorticoidsmyocardial infarctionthymocytethymusT lymphopoiesis

Identifiers

PMID38995212
PMCPMC11442026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.