Evidence map›Paper›PMID 38995033›Full record

ArticleAntimicrobial agents and chemotherapy2024

Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in

Stephanie L Egge, Samie A Rizvi, Shelby R Simar, Manuel Alcalde, Jose R W Martinez, Blake M Hanson, An Q Dinh, Rodrigo P Baptista, Truc T Tran, Samuel A Shelburne and 4 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Mechanisms involved in cefiderocol resistance in FrenchAntimicrobial agents and chemotherapy · 2026
    Article
  4. Review
  5. Article
  6. Genetic basis of cefiderocol resistance inMicrobiology spectrum · 2026
    Article
  7. Article
  8. Article
  9. MexS mediated heteroresistance ofFrontiers in microbiology · 2026
    Article
  10. Article
  11. Review
  12. Siderophore cephalosporins.EcoSal Plus · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Stephanie L EggeDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0001-8232-0443
Samie A RizviDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.
Shelby R SimarUTHealth Houston School of Public Health, University of Texas Health Science Center, Houston, Texas, USA.
Manuel AlcaldeInstituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina Clinica Alemana, Universidad del Desarrollo and Multidisciplinary Initiative for Collaborative Research On Bacterial Resistance (MICROB-R), Santiago, Chile.
Jose R W MartinezInstituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina Clinica Alemana, Universidad del Desarrollo and Multidisciplinary Initiative for Collaborative Research On Bacterial Resistance (MICROB-R), Santiago, Chile.
Blake M HansonUTHealth Houston School of Public Health, University of Texas Health Science Center, Houston, Texas, USA.ORCID 0000-0003-2949-7818
An Q DinhDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.
Rodrigo P BaptistaDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.
Truc T TranDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0002-2696-4196
Samuel A ShelburneDepartment of Infectious Diseases, Infection Control, and Employee Health, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-9721-263X
Jose M MunitaInstituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina Clinica Alemana, Universidad del Desarrollo and Multidisciplinary Initiative for Collaborative Research On Bacterial Resistance (MICROB-R), Santiago, Chile.
Cesar A AriasDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0001-9054-9774
Morgan HakkiDepartment of Medicine, Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA.
William R MillerDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0002-1518-2973

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SAVIDGE, TOR C. · 2020 to 2025
$12.0M
VENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
Molecular Basis of Infectious Diseases Training GrantT32AI055449 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LORENZ, MICHAEL C · 2005 to 2025
$2.6M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Texas Medical Center Training Program in Antimicrobial ResistanceT32AI141349 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2019 to 2023
$1.3M
Emergence of TonB-dependent receptor mediated cefiderocol resistance among multidrug-resistant (MDR) Pseudomonas aeruginosa clinical isolates.R21AI175821 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI MILLER, WILLIAM R · 2023 to 2024
$467k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI121296HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI134637HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI141349HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI148342HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI152999HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI175821NIAID NIH HHS K24 AI121296NIAID NIH HHS P01 AI152999NIAID NIH HHS R01 AI134637NIAID NIH HHS R01 AI148342NIAID NIH HHS R21 AI175821NIAID NIH HHS T32 AI055449NIAID NIH HHS T32 AI141349
6 · The paper itself

Abstract

The siderophore-cephalosporin cefiderocol (FDC) presents a promising treatment option for carbapenem-resistant (CR)

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCefiderocolMicrobial Sensitivity TestsMutationPseudomonas aeruginosaCephalosporinsDrug Resistance, BacterialHumansMembrane ProteinsPseudomonas InfectionsAnti-Bacterial AgentsBacterial ProteinsCefiderocolCephalosporinsMembrane ProteinstonB protein, Bacteriabeta-lactamasescefiderocolGram-negative resistanceheteroresistancemulti-drug resistancePseudomonas aeurginosaTonB-dependent receptor

Identifiers

PMID38995033
PMCPMC11304687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.