Evidence map›Paper›PMID 38995009›Full record

ArticleCells2024

Precise Serial Microregistration Enables Quantitative Microscopy Imaging Tracking of Human Skin Cells In Vivo.

Yunxian Tian, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Sunil Kalia, InSeok Seo, Hao Ou-Yang, Haishan Zeng

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunxian TianImaging Unit, Integrative Oncology Department, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Zhenguo WuImaging Unit, Integrative Oncology Department, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0001-8086-9432
Harvey LuiImaging Unit, Integrative Oncology Department, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Jianhua ZhaoImaging Unit, Integrative Oncology Department, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Sunil KaliaPhotomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC V5Z 4E8, Canada.
InSeok SeoJohnson and Johnson Consumer Inc., Skillman, NJ 08558, USA.
Hao Ou-YangJohnson and Johnson Consumer Inc., Skillman, NJ 08558, USA.
Haishan ZengImaging Unit, Integrative Oncology Department, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0003-3557-2407

Funding

BC Hydro Employees Community Service Fund N/ACanadian Dermatology Foundation N/ACIHR MOP130548Johnson and Johnson Consumer Inc. N/AVGH & UBC Hospital Foundation N/A
6 · The paper itself

Abstract

We developed an automated microregistration method that enables repeated in vivo skin microscopy imaging of the same tissue microlocation and specific cells over a long period of days and weeks with unprecedented precision. Applying this method in conjunction with an in vivo multimodality multiphoton microscope, the behavior of human skin cells such as cell proliferation, melanin upward migration, blood flow dynamics, and epidermal thickness adaptation can be recorded over time, facilitating quantitative cellular dynamics analysis. We demonstrated the usefulness of this method in a skin biology study by successfully monitoring skin cellular responses for a period of two weeks following an acute exposure to ultraviolet light.

Indexed as

SkinCell MovementCell ProliferationCell TrackingHumansMicroscopyMicroscopy, Fluorescence, MultiphotonUltraviolet Raysepidermalhuman skinin vivo cell trackingin vivo cellular imagingin vivo microscopylongitudinal studymelaninmultiphoton microscopyreflectance confocal microscopysecond harmonic generationtwo-photon excitation fluorescenceUV radiation

Identifiers

PMID38995009
PMCPMC11240548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.