Evidence map›Paper›PMID 38995000›Full record

ArticleCells2024

Global Transcriptomic and Characteristics Comparisons between Mouse Fetal Liver and Bone Marrow Definitive Erythropoiesis.

Chengjie Gao, Huan Zhang, Yaomei Wang, Shihui Wang, Xinhua Guo, Yongshuai Han, Huizhi Zhao, Xiuli An

Abstract readComparative Study
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chengjie GaoSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.ORCID 0009-0002-7453-7743
Huan ZhangSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.ORCID 0009-0009-1420-0154
Yaomei WangLaboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA.ORCID 0009-0004-0234-965X
Shihui WangInstitute of Hematology, People's Hospital of Zhengzhou University, Zhengzhou 450003, China.
Xinhua GuoLaboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA.
Yongshuai HanLaboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA.
Huizhi ZhaoSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.ORCID 0009-0005-5773-1968
Xiuli AnLaboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA.

Funding

Transfusion-driven hyperhemolysis in sickle cell diseaseR01HL165202 · NHLBI · NEW YORK BLOOD CENTER · PI Xiuli An, HUI ZHONG · 2023 to 2026
$3.2M
NIH HHS 1R01HL165202-23A1NIH HHS 1R01HL165202-24A1
6 · The paper itself

Abstract

Erythropoiesis occurs first in the yolk sac as a transit "primitive" form, then is gradually replaced by the "definitive" form in the fetal liver (FL) during fetal development and in the bone marrow (BM) postnatally. While it is well known that differences exist between primitive and definitive erythropoiesis, the similarities and differences between FL and BM definitive erythropoiesis have not been studied. Here we performed comprehensive comparisons of erythroid progenitors and precursors at all maturational stages sorted from E16.5 FL and adult BM. We found that FL cells at all maturational stages were larger than their BM counterparts. We further found that FL BFU-E cells divided at a faster rate and underwent more cell divisions than BM BFU-E. Transcriptome comparison revealed that genes with increased expression in FL BFU-Es were enriched in cell division. Interestingly, the expression levels of glucocorticoid receptor

Indexed as

Bone MarrowErythropoiesisFetusLiverTranscriptomeAnimalsErythroid Precursor CellsFemaleGene Expression Regulation, DevelopmentalMiceMice, Inbred C57BLbone marrowcell cycledefinitive erythropoiesisfetal livertranscriptome analysis

Identifiers

PMID38995000
PMCPMC11240549

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.