Evidence map›Paper›PMID 38994995›Full record

ReviewCells2024

Heavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington's Disease.

Yousef Tizabi, Samia Bennani, Nacer El Kouhen, Bruk Getachew, Michael Aschner

Abstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yousef TizabiDepartment of Pharmacology, Howard University College of Medicine, Washington, DC 20059, USA.ORCID 0000-0003-1703-1842
Samia BennaniFaculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca 20670, Morocco.ORCID 0009-0001-5800-1044
Nacer El KouhenFaculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca 20670, Morocco.
Bruk GetachewDepartment of Pharmacology, Howard University College of Medicine, Washington, DC 20059, USA.ORCID 0000-0003-3523-2154
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-2619-1656

Funding

The Howard University SCORE Program Supplemental GrantS06GM008016 · NIGMS · HOWARD UNIVERSITY · PI LITTLETON, GEORGE K · 1989 to 2009
$16.1M
Mechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9M
Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
Novel Interventions in Alcohol Induced DepressionR03AA022479 · NIAAA · HOWARD UNIVERSITY · PI TIZABI, YOUSEF · 2014 to 2015
$149k
NIAAA NIH HHS R03 AA022479NIEHS NIH HHS R01 ES007331NIEHS NIH HHS R01 ES010563NIEHS NIH HHS R01ES10563 and R01ES07331NIGMS NIH HHS S06 GM008016NIH/NIGMS 2 SO6 GM08016-39
6 · The paper itself

Abstract

Huntington's disease (HD) is a rare but progressive and devastating neurodegenerative disease characterized by involuntary movements, cognitive decline, executive dysfunction, and neuropsychiatric conditions such as anxiety and depression. It follows an autosomal dominant inheritance pattern. Thus, a child who has a parent with the mutated huntingtin (

Indexed as

Gastrointestinal MicrobiomeHuntington DiseaseMetals, HeavyNeurogliaAnimalsHumansMetals, Heavycopperglial cellsgut–brain axisgut microbiotaheavy metalsHuntington’s diseaseironmanganeseneuroinflammation

Identifiers

PMID38994995
PMCPMC11240758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.