Evidence map›Paper›PMID 38994984›Full record

ArticleCells2024

HPV Detection in Breast Tumors and Associated Risk Factors in Northeastern Brazil.

Kamylla Conceição Gomes Nascimento, Bianca de França São Marcos, Pedro Henrique Bezerra Fontes, Beatriz Eda de Oliveira Isídio, Stephanie Loureiro Leão, Gabriel Romulo Parente da Silva, David Beltrán Lussón, Daffany Luana Dos Santos, Lígia Rosa Sales Leal, Benigno Cristofer Flores Espinoza and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kamylla Conceição Gomes NascimentoLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Bianca de França São MarcosLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Pedro Henrique Bezerra FontesLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Beatriz Eda de Oliveira IsídioLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Stephanie Loureiro LeãoLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Gabriel Romulo Parente da SilvaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
David Beltrán LussónLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Daffany Luana Dos SantosLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Lígia Rosa Sales LealLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Benigno Cristofer Flores EspinozaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.ORCID 0000-0001-8185-9818
Larissa Silva de MacêdoLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.ORCID 0000-0003-1660-4901
Pedro Luiz de França NetoLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Anna Jéssica Duarte SilvaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.ORCID 0000-0002-8341-7877
Jacinto Costa Silva NetoLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.ORCID 0000-0003-4418-801X
Vanessa Emanuelle Pereira SantosLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.
Antonio Carlos de FreitasLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235. Cidade Universitária Recife, Pernambuco, Recife 50670901, PE, Brazil.ORCID 0000-0002-4957-9549

Funding

National Council for Scientific and Technological Development 308684/2023-0National Council for Scientific and Technological Development 444156/2023-2National Council for Scientific and Technological Development 444606/2023-8
6 · The paper itself

Abstract

Breast cancer risk factors include lifestyle, genetic-hormonal influences, and viral infections. Human papillomavirus (HPV), known primarily as the etiological agent of cervical cancer, also appears active in breast carcinogenesis, as evidenced in our study of 56 patients from northeastern Brazil. We assessed the clinical and sociodemographic characteristics, correlating them with various breast cancer tumor types. HPV detection involved amplifying the L1 region, with viral load measured using the E2/E6 ratio and viral activity indicated by E5 oncogene expression. Predominantly, patients over 56 years of age with healthy lifestyles showed a high incidence of invasive ductal carcinoma and triple-negative breast cancer. HPV was detected in 35.7% of cases, mostly HPV16, which is associated with high viral loads (80 copies per cell) and significant E5 expression. These results hint at a possible link between HPV and breast carcinogenesis, necessitating further studies to explore this association and the underlying viral mechanisms.

Indexed as

Breast NeoplasmsPapillomavirus InfectionsAdultAgedBrazilFemaleHumansMiddle AgedPapillomaviridaeRisk FactorsViral Loadbreast cancerE5 oncogeneHPV16invasive ductal carcinomalifestylesociodemographictriple-negative

Identifiers

PMID38994984
PMCPMC11240692

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.