Evidence map›Paper›PMID 38994980›Full record

ArticleCells2024

Inhibition of Vascular Smooth Muscle Cell Proliferation by ENPP1: The Role of CD73 and the Adenosine Signaling Axis.

Boris Tchernychev, Yvonne Nitschke, Di Chu, Caitlin Sullivan, Lisa Flaman, Kevin O'Brien, Jennifer Howe, Zhiliang Cheng, David Thompson, Daniel Ortiz and 2 more

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Boris TchernychevResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.
Yvonne NitschkeDepartment of General Pediatrics, Münster University Children's Hospital, 48149 Münster, Germany.
Di ChuResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.
Caitlin SullivanResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.
Lisa FlamanResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.ORCID 0000-0002-2226-1223
Kevin O'BrienResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.ORCID 0009-0006-8197-1803
Jennifer HoweResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.ORCID 0009-0001-0958-0983
Zhiliang ChengResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.
David ThompsonResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.
Daniel OrtizResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.
Frank RutschDepartment of General Pediatrics, Münster University Children's Hospital, 48149 Münster, Germany.ORCID 0000-0003-2385-4159
Yves SabbaghResearch and Development, Inozyme Pharma, 321 Summer St, Suite 400, Boston, MA 02201, USA.ORCID 0000-0001-5339-6705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) ectoenzyme regulates vascular intimal proliferation and mineralization of bone and soft tissues.

Indexed as

5'-NucleotidaseAdenosineCell ProliferationMuscle, Smooth, VascularMyocytes, Smooth MusclePhosphoric Diester HydrolasesPyrophosphatasesSignal TransductionAdenosine MonophosphateAnimalsCyclic AMPHumansMaleMiceMice, Inbred C57BLVascular Calcification5'-NucleotidaseAdenosineAdenosine MonophosphateCyclic AMPectonucleotide pyrophosphatase phosphodiesterase 1Phosphoric Diester HydrolasesPyrophosphatasesneointimapurinergic signalingvascular smooth muscle cells

Identifiers

PMID38994980
PMCPMC11240470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.