James German and the Quest to Understand Human RECQ Helicase Deficiencies.

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In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Raymond J MonnatDepartments of Laboratory Medicine/Pathology and Genome Sciences, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-7638-7393

Funding

Tumor mutation signaturesP01CA077852 · NCI · UNIVERSITY OF WASHINGTON · PI MONNAT, RAYMOND J · 1999 to 2019

$26.0M

RECQ2016 - Partnering for ProgressR13CA206251 · NCI · UNIVERSITY OF WASHINGTON · PI MONNAT, RAYMOND J · 2016 to 2016

$8k

NCI NIH HHS P01 CA077852NCI NIH HHS R13 CA206251NIH HHS NCI P01CA077852NIH HHS NIH R13CA206251-01Nippon Boehringer Ingelheim Virtual Research Institute of Aging Research Program Research grant 2001-2004

6 · The paper itself

Abstract

James German's work to establish the natural history and cancer risk associated with Bloom syndrome (BS) has had a strong influence on the generation of scientists and clinicians working to understand other RECQ deficiencies and heritable cancer predisposition syndromes. I summarize work by us and others below, inspired by James German's precedents with BS, to understand and compare BS with the other heritable RECQ deficiency syndromes with a focus on Werner syndrome (WS). What we know, unanswered questions and new opportunities are discussed, as are potential ways to treat or modify WS-associated disease mechanisms and pathways.

Indexed as

Bloom SyndromeRecQ HelicasesWerner SyndromeHistory, 20th CenturyHumansRecQ HelicasesBloom syndromecancer predisposition syndromeprogeroid syndromeRECQ helicase deficiency syndromeWerner syndrome

Identifiers

PMID38994931

DOI10.3390/cells13131077

PMCPMC11240319

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.