Evidence map›Paper›PMID 38994626›Full record

ArticleCombinatorial chemistry & high throughput screening2025

Juveriya Israr, Mohsin Ali Khan, Sankalp Misra, Divya Gupta, Nootan Singh, Rumana Ahmad, Sahabjada Siddiqui

Abstract read
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Article in Combinatorial chemistry & high throughput screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juveriya IsrarFaculty of Biosciences, Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Lucknow- Deva Road, Barabanki, India.
Mohsin Ali KhanResearch and Development Unit, Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
Sankalp MisraFaculty of Biosciences, Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Lucknow- Deva Road, Barabanki, India.
Divya GuptaFaculty of Biosciences, Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Lucknow- Deva Road, Barabanki, India.
Nootan SinghFaculty of Biosciences, Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Lucknow- Deva Road, Barabanki, India.
Rumana AhmadDepartment of Biochemistry, Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
Sahabjada SiddiquiDepartment of Biotechnology, Era University, Lucknow, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral cancer poses a significant threat to public health worldwide. In addition, because many chemotherapy treatments have negative side effects, natural herbs may be beneficial for oral cancer therapy. Achyranthes aspera (AA), a potential medicinal herb, exerts various pharmacological and biochemical activities.

objectiveThe present study aimed to predict the anti-oral cancer potential of AA using in silico tools and cell death by in vitro testing.

methodsA total of fourteen bioactive constituents from AA herb were selected using phytochemical databases. The toxicity of AA herb extract was analysed through MTT assay against oral carcinoma A253 cell line. The binding activities of the phytocomponents against serine/ threonine-specific protein kinases isoforms, namely Akt1 (PDB ID: 3qkk) and Akt2 (PDB ID: 2jdo) proteins, were analysed using Discovery Studio 2021 and PyRx docking software.

resultsCell viability data revealed that AA extract decreased the viability and reduced the number of live cells of the oral carcinoma A253 cell line in a dose-dependent manner. The halfmaximal concentration (IC

conclusionThe present findings reveal that the lead phytomolecules of AA could be effective and developed as a prospective drug against oral cancer.

Indexed as

AchyranthesAntineoplastic Agents, PhytogenicMouth NeoplasmsPhytochemicalsPlant ExtractsCell Line, TumorCell ProliferationCell SurvivalComputer SimulationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureProto-Oncogene Proteins c-aktStructure-Activity RelationshipAntineoplastic Agents, PhytogenicPhytochemicalsPlant ExtractsProto-Oncogene Proteins c-aktAchyranthes asperaAkt1Akt2cytotoxicitymolecular docking.Oral squamous cell carcinomaphytoconstituents

Identifiers

PMID38994626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.