Evidence map›Paper›PMID 38994482›Full record

ArticleBladder cancer (Amsterdam, Netherlands)2023

An Association Study of Germline Variants in Bladder Cancer-Related Genes with the Prognosis of Non-Muscle Invasive Bladder Cancer.

Jasper P Hof, Sita H Vermeulen, Antoine G van der Heijden, Gerald W Verhaegh, Lars Dyrskjøt, James W F Catto, Lourdes Mengual, Richard T Bryan, Neil E Fleshner, Lambertus A L M Kiemeney and 1 more

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Article in Bladder cancer (Amsterdam, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jasper P HofDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
Sita H VermeulenDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
Antoine G van der HeijdenDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Gerald W VerhaeghDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Lars DyrskjøtDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
James W F CattoAcademic Urology Unit, University of Sheffield, Sheffield, UK.
Lourdes MengualDepartment and Laboratory of Urology, Universitat de Barcelona, Barcelona, Spain.
Richard T BryanInstitute of Cancer & Genomic Sciences, Bladder Cancer Research Centre, University of Birmingham, Birmingham, UK.
Neil E FleshnerDepartment of Urology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Lambertus A L M KiemeneyDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
Tessel E GaleslootDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVarious germline genetic variants are associated with the prognosis of non-muscle invasive bladder cancer (NMIBC). Germline variants in genes frequently somatically mutated in bladder cancer have not been studied thoroughly in relation to risk of recurrence or progression in NMIBC.

objectiveTo identify germline DNA variants in bladder carcinogenesis-related genes associated with recurrence or progression in NMIBC.

methodsWe analysed associations between single-nucleotide polymorphisms (SNPs) and NMIBC recurrence and progression using data from the Nijmegen Bladder Cancer Study (NBCS, 1,443 patients). We included 5,053 SNPs within 46 genes known to have mutation, overexpression or amplification in bladder cancer. We included all recurrences in the statistical analysis and performed both single variant analysis and gene-based analysis. SNPs and genes that showed significant or suggestive association (false discovery rate P value < 20%) were followed-up in independent cohorts for replication analysis, through eQTL analysis and tests for association of tumour expression levels with NMIBC recurrence and progression.

resultsSingle variant analysis showed no statistically significant associations with recurrence or progression. In gene-based analysis, the aggregate effect of the 25 SNPs in the Cyclin D1 gene (

conclusionsWe could not identify reproducible associations between common germline variants in bladder carcinogenesis-related genes and NMIBC recurrence or progression.

Indexed as

Bladder cancercandidate gene analysisgenetic association studyprogressionrecurrence

Identifiers

PMID38994482
PMCPMC11181778

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