ArticleChemical science2024
Divergent functionalization of alkenes enabled by photoredox activation of CDFA and α-halo carboxylic acids.
Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Fe-LMCT Photodecarboxylation for (Hetero)arene Chloro- and Bromodifluoromethylation: Rapid Access to Aromatic Acyl Fluorides.Organic letters · 2026Article
- Divergent Access to Fluorinated Pharmacons From Ethyl Trifluoropyruvate.Advanced synthesis & catalysis · 2026Article
- Triplet Energy Transfer-Mediated Intermolecular Paternò-Büchi Reaction for the Synthesis of Trifluoromethylated Oxetanes.Organic letters · 2026Article
- Radical/Ylide-Tunable Pyridinium Salt Enables Photo/Thermocatalytic Divergent [3 + 2] Cycloadditions.JACS Au · 2026Article
- Overcoming Challenges in Small-Ring Transfer: Direct Decarboxylative Hydroalkylation of Alkenes via Iron-Thiol Catalysis.Angewandte Chemie (International ed. in English) · 2025Article
- Fluorinated Radicals in Divergent Synthesis via Photoredox Catalysis.Accounts of chemical research · 2025Article
- Phenothiazine Sulfoxides as Active Photocatalysts for the Synthesis of γ-Lactones.Journal of the American Chemical Society · 2025Article
- Visible-Light-Mediated Vicinal Dihalogenation of Unsaturated C-C Bonds Using Dual-Functional Group Transfer Reagents.Journal of the American Chemical Society · 2024Article
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Authors and funding
3 authors.
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Abstract
Herein we present our studies on the solvent-controlled difunctionalization of alkenes utilizing chlorodifluoroacetic acid (CDFA) and α-halo carboxylic acids for the synthesis of γ-lactones, γ-lactams and α,α-difluoroesters. Mechanistic insights revealed that photocatalytic reductive mesolytic cleavage of the C-X bond delivers elusive α-carboxyl alkyl radicals. In the presence of an olefin molecule, this species acts as a unique bifunctional intermediate allowing for stipulated formation of C-O, C-N and C-H bonds on Giese-type adducts
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.