Evidence map›Paper›PMID 38994387›Full record

ArticleFrontiers in transplantation2022

Pre-engraftment neurological impairment in allogeneic stem cell transplant: A case report of atypical posterior reversible encephalopathy syndrome with pontine involvement.

Andrea Acerbis, Giorgio Orofino, Edoardo Campodonico, Anna Del Poggio, Elisabetta Xue, Francesca di Matteo, Greta Spelta, Alessandro Bruno, Andrea Falini, Fabio Ciceri and 2 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

12 authors.

Andrea AcerbisHematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Giorgio OrofinoHematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Edoardo CampodonicoHematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Anna Del PoggioDepartment of Neuroradiology and CERMAC, San Raffaele Hospital, Milan, Italy.
Elisabetta XueHematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Francesca di MatteoVita-Salute San Raffaele University, Milan, Italy.
Greta SpeltaVita-Salute San Raffaele University, Milan, Italy.
Alessandro BrunoHematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Andrea FaliniVita-Salute San Raffaele University, Milan, Italy.
Fabio CiceriHematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Jacopo PeccatoriHematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Raffaella GrecoHematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present report, we describe the case of a 59-year-old female who developed pre-engraftment multiple organ failure (MOF) after allogeneic hematopoietic stem cell transplant (HSCT), followed a few days later by a cohort of neurological symptoms leading to a diagnosis of posterior reversible encephalopathy syndrome (PRES). The diagnosis was achieved by excluding more frequent entities associated with neurological symptoms in HSCT and supported by compatible magnetic resonance imaging (MRI) findings, with remarkably interesting less frequent pontine involvement. GvHD prophylaxis, including sirolimus and mycophenolate mofetil (MMF), was discontinued, while carefully controlling blood pressure. In addition, high-dose steroids were employed. After 2 weeks, the neurological symptoms abated, and follow-up MRI showed a complete regression of neurological alterations, confirming the diagnostic hypothesis of PRES.

Indexed as

allogeneicbone marrow translation (BMT)neuroimagingneurological complicationsPRES—posterior reversible encephalopathy syndrome

Identifiers

PMID38994387
PMCPMC11235297

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