ArticleFrontiers in transplantation2022
Temporal and spatial variability of immunosuppressive therapies in transplant patients: An observational study in Italy.
Article in Frontiers in transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Age-specific impact of different immunosuppressive regimens on kidney transplant outcomes: clinical evidence from the scientific registry of transplant recipients.Frontiers in nephrology · 2026Article
- A population-based analysis of immunosuppression therapy after organ transplantation.BMC health services research · 2025Article
- Maintenance immunosuppressive therapy in liver transplantation: results from CESIT study, an Italian retrospective cohort study.BMJ open · 2024Article
- Immunosuppression with Generics in Liver and Kidney Transplantation: A Real-World Evidence Study.Drug design, development and therapy · 2024Observational
- Effectiveness and safety of immunosuppressive regimens used as maintenance therapy in kidney transplantation: The CESIT study.PloS one · 2024Observational
- Determinants of immunosuppressive therapy in renal transplant recipients: an Italian observational study (the CESIT project).BMC nephrology · 2023Observational
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Authors and funding
25 authors.
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Abstract
Background: In immunosuppression after transplantation, several multi-drug approaches are used, involving calcineurin inhibitors ( Methods: An Italian multicentre observational cohort study was conducted using health information systems. Patients with incident transplant during 2009-2019 and resident in four regions (Veneto, Lombardy, Lazio, and Sardinia) were enrolled. The post-transplant immunosuppressive regimen was evaluated by organ, region, and year. Results: The most dispensed regimen was triple-drug therapy for the kidneys [tacrolimus (TAC) + antiM + corticosteroids = 41.5%] and heart [cyclosporin + antiM + corticosteroids = 36.6%] and double-drug therapy for liver recipients (TAC + corticosteroids = 35.4%). Several differences between regions and years emerged with regard to agents and the number of drugs used. Conclusion: A high heterogeneity in immunosuppressive therapy post-transplant was found. Further studies are needed in order to investigate the reasons for this variability and to evaluate the risk-benefit profile of treatment schemes adopted in clinical practice.
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