Evidence map›Paper›PMID 38994135›Full record

ReviewWorld journal of gastrointestinal oncology2024

Therapeutic strategies targeting the epidermal growth factor receptor signaling pathway in metastatic colorectal cancer.

Yi Zhou, Shuang Wu, Fan-Jie Qu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yi ZhouDepartment of Oncology, Affiliated Dalian Third People's Hospital of Dalian Medical University, Dalian 116033, Liaoning Province, China.
Shuang WuDepartment of Oncology, Affiliated Dalian Third People's Hospital of Dalian Medical University, Dalian 116033, Liaoning Province, China.
Fan-Jie QuDepartment of Oncology, Affiliated Dalian Third People's Hospital of Dalian Medical University, Dalian 116033, Liaoning Province, China. wyb960419@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More than 1.9 million new colorectal cancer (CRC) cases and 935000 deaths were estimated to occur worldwide in 2020, representing about one in ten cancer cases and deaths. Overall, colorectal ranks third in incidence, but second in mortality. More than half of the patients are in advanced stages at diagnosis. Treatment options are complex because of the heterogeneity of the patient population, including different molecular subtypes. Treatments have included conventional fluorouracil-based chemotherapy, targeted therapy, immunotherapy,

Indexed as

B-type RAF mutationEpidermal growth factor receptorHuman epidermal growth factor receptor 2 overexpression/ amplificationKirsten rat sarcoma viral oncogene G12C mutationKirsten rat sarcoma viral oncogene wild typeMetastatic colorectal cancer

Identifiers

PMID38994135
PMCPMC11236217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.