Evidence map›Paper›PMID 38994044›Full record

ArticleHeliyon2024

The gingival crevicular fluid biomarkers with micropulse vibration device: A pilot study.

Liying Luo, Chengling Xu, Yao Li, Chunbo Hao, Jiao Zheng, Xiao Jin, Jiani Yu, Yuchang Zhu, Zhiqiang Guan, Qin Yin

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The Role of Cytokines in Orthodontic Tooth Movement.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Liying LuoDepartment of Ophthalmology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chengling XuAdministration Department of Nosocomial Infection, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yao LiNanjing Medical University, Nanjing, China.
Chunbo HaoDepartment of Ophthalmology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiao ZhengDepartment of Anorectal, Affiliated Municipal Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.
Xiao JinDepartment of Rheumatology and Immunology, Affiliated Municipal Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221000, China.
Jiani YuDepartment of Rheumatology and Immunology, Affiliated Municipal Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221000, China.
Yuchang ZhuNanjing Medical University, Nanjing, China.
Zhiqiang GuanDepartment of Dermatology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu, 221002, China.
Qin YinDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The aim of this study is to investigate the impact of vibration stimulation on gingival crevicular fluid biomarkers and orthodontic tooth movement. Methods: Forty patients were randomly assigned to receive therapy with an intraoral vibration device (n = 20, AcceleDent®) or no treatment (n = 20) at a university orthodontic clinic. The quantity of fluid in the gingival sulcus, biomarkers of each fluid in the gingival sulcus, and orthodontic tooth movement were analyzed at three-time intervals (T1, T2, T3) before and after therapy (T0). Results: The results showed that vibration treatment led to higher levels of osteoclast biomarkers (RNAKL, RANKL/OPG) and inflammatory biomarkers (TNF-, IL-11, IL-18) compared to the control group. Additionally, vibration treatment at T1, T2, and T3 significantly improved tooth mobility and GCF volume. The gingival crevicular fluid biomarker levels of the T0, T1, and T2 vibration groups, as well as IL-11, IL-18, TGF-1, and TNF-α vibration groups, were significantly higher than those of the control group at different time points. Conclusion: vibration therapy was found to be closely associated with bone-breaking cells and inflammatory factor levels.

Indexed as

Gingival crevicular fluidOrthodontic tooth movementVibration

Identifiers

PMID38994044
PMCPMC11237842

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.