Evidence map›Paper›PMID 38993862›Full record

ArticleFrontiers in transplantation2023

Comprehensive immune profiling of SARS-CoV-2 infected kidney transplant patients.

Franz Fenninger, Karen R Sherwood, Vivian Wu, Paaksum Wong, Mari L DeMarco, Meng Wang, Vincent Benedicto, Krishna A Dwarka, Oliver P Günther, Logan Tate and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Franz Fenninger *Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Karen R Sherwood *Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Vivian WuDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Paaksum WongDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Mari L DeMarcoDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Meng WangDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Vincent BenedictoBC Provincial Immunology Laboratory, Vancouver Coastal Health, Vancouver, BC, Canada.
Krishna A DwarkaDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Oliver P GüntherGünther Analytics, Vancouver, BC, Canada.
Logan TateDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Eric YoshidaDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Paul A KeownDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Matthew KadatzDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
James H LanDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The immune responses of kidney transplant recipients against SARS-CoV-2 remains under studied. Methods: In this prospective pilot study, we performed comprehensive immune profiling using cellular, proteomic, and serologic assays on a cohort of 9 kidney transplant recipients and 12 non-transplant individuals diagnosed with COVID-19. Results: Our data show that in addition to having reduced SARS-CoV-2 specific antibody levels, kidney transplant recipients exhibited significant cellular differences including a decrease in naïve-but increase in effector T cells, a high number of CD28+ CD4 effector memory T cells, and increased CD8 T memory stem cells compared with non-transplant patients. Furthermore, transplant patients had lower concentrations of serum cytokine MIP-1β as well as a less diverse T cell receptor repertoire. Conclusion: Overall, our results show that compared to non-transplant patients, kidney transplant recipients with SARS-CoV-2 infection exhibit an immunophenotype that is reminiscent of the immune signature observed in patients with severe COVID-19.

Indexed as

chronic kidney diseaseCOVID-19cytokine profilingimmune profilingimmunophenotypingkidney transplantationSARS-CoV-2TCR sequencing

Identifiers

PMID38993862
PMCPMC11235348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.