Evidence map›Paper›PMID 38993845›Full record

ArticleFrontiers in transplantation2023

Highly sensitised individuals present a distinct Treg signature compared to unsensitised individuals on haemodialysis.

C Dudreuilh, S Basu, O Shaw, H Burton, N Mamode, F Harris, T Tree, P Nedyalko, M Terranova-Barberio, G Lombardi and 2 more

Abstract read
In one paragraph

Article in Frontiers in transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Activation and Regulation of Indirect Alloresponses in Transplanted Patients With Donor Specific Antibodies and Chronic Rejection.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

C DudreuilhDepartment of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
S BasuDepartment of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
O ShawSynnovis Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom.
H BurtonDepartment of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
N MamodeDepartment of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
F HarrisPeter Gorer Department of Immunobiology, King's College London, London, United Kingdom.
T TreePeter Gorer Department of Immunobiology, King's College London, London, United Kingdom.
P NedyalkoNIHR Guy's and St Thomas' Biomedical Research Centre at Guy's and St Thomas NHS Foundation Trust, St Thomas' Hospital, London, United Kingdom.
M Terranova-BarberioNIHR Guy's and St Thomas' Biomedical Research Centre at Guy's and St Thomas NHS Foundation Trust, St Thomas' Hospital, London, United Kingdom.
G LombardiPeter Gorer Department of Immunobiology, King's College London, London, United Kingdom.
C ScottàPeter Gorer Department of Immunobiology, King's College London, London, United Kingdom.
A DorlingDepartment of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Highly sensitised (HS) patients represent up to 30% of patients on the kidney transplant waiting list. When they are transplanted, they have a high risk of acute/chronic rejection and long-term allograft loss. Regulatory T cells (Tregs) (CD4 Methods: We recruited prospectively healthy volunteers (HV) ( Results: We compared the Treg phenotypes of HV, HD and HS. HS patients had more CD161 Discussion: This is the first study presenting a deep Treg phenotype in HS patients. We confirmed that HS patients had more of a Th17-like CD161

Indexed as

haemodialysishighly sensitisedregulatory T cellssensitisationT follicular regulatory cells

Identifiers

PMID38993845
PMCPMC11235238

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.