Evidence map›Paper›PMID 38993842›Full record

ReviewFrontiers in transplantation2023

Current practice and novel approaches in organ preservation.

Ozge Sila Ozgur, Bat-Erdene Namsrai, Timothy L Pruett, John C Bischof, Mehmet Toner, Erik B Finger, Korkut Uygun

Abstract readReview
In one paragraph

Review in Frontiers in transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. OxyVitaInternational journal of molecular sciences · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Animal models for transplant immunology: bridging bench to bedside.Clinical transplantation and research · 2024
    Review
  16. Review
  17. Article
  18. Article
  19. iPSC-derived cells for whole liver bioengineering.Frontiers in bioengineering and biotechnology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ozge Sila OzgurDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Bat-Erdene NamsraiDepartment of Surgery, University of Minnesota, Minneapolis, MN, United States.
Timothy L PruettDepartment of Surgery, University of Minnesota, Minneapolis, MN, United States.
John C BischofDepartments of Mechanical and Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States.
Mehmet TonerDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Erik B FingerDepartment of Surgery, University of Minnesota, Minneapolis, MN, United States.
Korkut UygunDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Funding

Organ banking for transplant—kidney cryopreservation by vitrification and novel nanowarming technologyR01DK117425 · NIDDK · UNIVERSITY OF MINNESOTA · PI JOHN C BISCHOF, Erik Brian Finger · 2018 to 2026
$4.9M
High subzero preservation of liver for transplantationR01DK114506 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET, UYGUN, KORKUT · 2017 to 2025
$4.4M
Metabolic Modeling for Cadaveric Organ ResuscitationR01DK096075 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UYGUN, KORKUT, YEH, HEIDI · 2012 to 2022
$3.9M
Genetic-engineered control of the immunogeneic state of vascular composite allografts during preservationR01EB028782 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Biju Parekkadan, Korkut Uygun · 2021 to 2026
$3.1M
Subzero Non-freezing preservation of whole mammalian organismsR21GM143659 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI UYGUN, KORKUT · 2022 to 2023
$462k
NIBIB NIH HHS R01 EB028782NIDDK NIH HHS R01 DK096075NIDDK NIH HHS R01 DK114506NIDDK NIH HHS R01 DK117425NIGMS NIH HHS R21 GM143659
6 · The paper itself

Abstract

Organ transplantation remains the only treatment option for patients with end-stage organ failure. The last decade has seen a flurry of activity in improving organ preservation technologies, which promise to increase utilization in a dramatic fashion. They also bring the promise of extending the preservation duration significantly, which opens the doors to sharing organs across local and international boundaries and transforms the field. In this work, we review the recent literature on machine perfusion of livers across various protocols in development and clinical use, in the context of extending the preservation duration. We then review the next generation of technologies that have the potential to further extend the limits and open the door to banking organs, including supercooling, partial freezing, and nanowarming, and outline the opportunities arising in the field for researchers in the short and long term.

Indexed as

isochoric preservationliver preservationmachine perfusionnanowarmingorgan transplantationpartial freezingsubzero preservationsupercooling

Identifiers

PMID38993842
PMCPMC11235303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.