Evidence map›Paper›PMID 38993738›Full record

ArticleJournal of hematology2024

Non-Secretory Multiple Myeloma Associated With High-Risk Phenotype and Complex Cytogenetics Including t(8;22).

Rahim A Jiwani, Joseph R Liput, Attah Abraham, Khaled Alhamad, Mukta Kapdi, Renan Mota, Kayla Forte, John R McGill, Jasper C Acer, Palgun Nisarga and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rahim A JiwaniDivision of Hematology and Medical Oncology, Allegheny Health Network, Pittsburgh, PA, USA.
Joseph R LiputDivision of Hematology and Medical Oncology, Allegheny Health Network, Pittsburgh, PA, USA.
Attah AbrahamDivision of Internal Medicine, Allegheny Health Network, Pittsburgh, PA, USA.
Khaled AlhamadDivision of Internal Medicine, Allegheny Health Network, Pittsburgh, PA, USA.
Mukta KapdiDivision of Internal Medicine, Allegheny Health Network, Pittsburgh, PA, USA.
Renan MotaNeoGenomics Laboratories, Fort Myers, FL, USA.
Kayla ForteNeoGenomics Laboratories, Fort Myers, FL, USA.
John R McGillNeoGenomics Laboratories, Fort Myers, FL, USA.
Jasper C AcerThe Lake Erie College of Osteopathic Medicine, Seton Hill Campus, Greensburg, PA, USA.
Palgun NisargaDivision of Pathology and Laboratory Medicine, Allegheny Health Network, Pittsburgh, PA, USA.
Nicholas R JaegerDivision of Pathology and Laboratory Medicine, Allegheny Health Network, Pittsburgh, PA, USA.
Santhosh SadashivDivision of Hematology and Cellular Therapy, Allegheny Health Network, Pittsburgh, PA, USA.
Prerna MewawallaDivision of Hematology and Cellular Therapy, Allegheny Health Network, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma (MM) is a plasma cell dyscrasia which is typically characterized by identifiable paraprotein in the blood or urine. However, the minority of patients in whom paraprotein cannot be identified are designated non-secretory MM (NSM). Evaluation of treatment response is more difficult in these patients as paraprotein levels cannot be followed. A dearth of clinical trials including these patients exists because of an inability to measure response by classical serum and urine measurement mechanisms as well as seemingly decreased overall survival compared to secretory MM. NSM is subdivided into four subgroups: "non-producers", "true non-secretors", "oligosecretors" and "false non-secretors". The "non-producers" phenotype is associated with more aggressive disease course. Translocations such as those involving the proto-oncogene

Indexed as

c-MYCCytogeneticsMultiple myeloma

Identifiers

PMID38993738
PMCPMC11236352

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.