ArticleiScience2024
Thalamocortical interactions shape hierarchical neural variability during stimulus perception.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Efficient and reliable spike sorting from neural recordings with UMAP-based unsupervised nonlinear dimensionality reduction.PLoS biology · 2025Article
- Hierarchical gradients of multiple timescales in the mammalian forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hierarchical unimodal processing within the primary somatosensory cortex during a bimodal detection task.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The brain is organized hierarchically to process sensory signals. But, how do functional connections within and across areas contribute to this hierarchical order? We addressed this problem in the thalamocortical network, while monkeys detected vibrotactile stimulus. During this task, we quantified neural variability and directed functional connectivity in simultaneously recorded neurons sharing the cutaneous receptive field within and across VPL and areas 3b and 1. Before stimulus onset, VPL and area 3b exhibited similar fast dynamics while area 1 showed slower timescales. During the stimulus presence, inter-trial neural variability increased along the network VPL-3b-1 while VPL established two main feedforward pathways with areas 3b and 1 to process the stimulus. This lower variability of VPL and area 3b was found to regulate feedforward thalamocortical pathways. Instead, intra-cortical interactions were only anticipated by higher intrinsic timescales in area 1. Overall, our results provide evidence of hierarchical functional roles along the thalamocortical network.
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