Evidence map›Paper›PMID 38993672›Full record

ArticleiScience2024

Optimizing treatment administration strategies using negative mNGS results in corticosteroid-sensitive diffuse parenchymal lung diseases.

Chuwei Jing, Yuchen Ding, Ji Zhou, Qun Zhang, Mingyue Wang, Qiuxiang Ou, Jia Liu, Ting Xv, Chunlai Feng, Dongmei Yuan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chuwei JingDepartment of Respiratory Medicine, Jiangsu Province Hospital/Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, China.
Yuchen DingDepartment of Respiratory Medicine, Jiangsu Province Hospital/Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, China.
Ji ZhouDepartment of Respiratory Medicine, Jiangsu Province Hospital/Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, China.
Qun ZhangDepartment of Respiratory Medicine, Jiangsu Province Hospital/Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, China.
Mingyue WangDepartment of Respiratory Medicine, Jiangsu Province Hospital/Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, China.
Qiuxiang OuResearch & Development, Dinfectome Inc., Nanjing, Jiangsu, China.
Jia LiuResearch & Development, Dinfectome Inc., Nanjing, Jiangsu, China.
Ting XvDepartment of Respiratory Medicine, School of Southeast University Affiliated Nanjing Chest Hospital, Nanjing, Jiangsu, China.
Chunlai FengDepartment of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Dongmei YuanDepartment of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Ting WuDepartment of Respiratory Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Ting WengNanjing Drum Tower Hospital Group Suqian Hospital, Jiangsu, China.
Xiaoyong XvSecond Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu, China.
Shanlin DaiDepartment of Respiratory Medicine, Jiangsu Province Hospital/Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, China.
Qian QianJiangsu Health Vocational College, Nanjing, Jiangsu, China.
Wenkui SunDepartment of Respiratory Medicine, Jiangsu Province Hospital/Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Timely adjustments of antibiotic and corticosteroid treatments are vital for patients with diffuse parenchymal lung diseases (DPLDs). In this study, 41 DPLD patients with negative metagenomic next-generation sequencing (mNGS) results who were responsive to corticosteroids were enrolled. Among these patients, about 26.8% suffered from drug-induced DPLD, while 9.8% presented autoimmune-related DPLD. Following the report of the negative mNGS results, in 34 patients with complete antibiotics administration profiles, 79.4% (27/34) patients discontinued antibiotics after receiving negative mNGS results. Moreover, 70.7% (29/41) patients began or increased the administration of corticosteroid upon receipt of negative mNGS results. In the microbiota analysis,

Indexed as

CancerMedical microbiologyPharmacology

Identifiers

PMID38993672
PMCPMC11237914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.