Evidence map›Paper›PMID 38993510›Full record

ArticleJournal of clinical and translational hepatology2024

Real-world Effectiveness and Tolerability of Interferon-free Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C: A Multinational Cohort Study.

Fanpu Ji, Sally Tran, Eiichi Ogawa, Chung-Feng Huang, Takanori Suzuki, Yu Jun Wong, Hidenori Toyoda, Dae Won Jun, Liu Li, Haruki Uojima and 91 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and translational hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

101 authors.

Fanpu JiDepartment of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Sally TranDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Eiichi OgawaDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan.
Chung-Feng HuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung.
Takanori SuzukiDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Yu Jun WongGastroenterology & Hepatology, Changi General Hospital, Singhealth, Singapore.
Hidenori ToyodaDepartment of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan.
Dae Won JunDepartment of Internal Medicine, Hanyang University, College of Medicine, Seoul, Korea.
Liu LiDepartment of Hepatology, The Third People's Hospital of Kunming City, Kunming, Yunnan, China.
Haruki UojimaDepartment of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Akito NozakiGastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Makoto ChumaGastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Cheng-Hao TsengDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung.
Yao-Chun HsuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung.
Masatoshi IshigamiDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takashi HondaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masanori AtsukawaDivision of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan.
Hiroaki HagaDepartment of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Masaru EnomotoDepartment of Transfusion Medicine and Department of Hepatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Huy TrinhSan Jose Gastroenterology, San Jose, CA, USA.
Carmen Monica PredaGastroenterology & Hepatology Department, Clinic Fundeni Institute, Bucharest, Romania.
Phillip VutienDivision of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA.
Charles LandisDivision of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA.
Dong Hyun LeeDepartment of Gastroenterology, Good Gang-An Hospital, Busan, Korea.
Tsunamasa WatanabeDivision of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki, Japan.
Hirokazu TakahashiLiver Center, Saga University Hospital, Saga, Japan.
Hiroshi AbeDivision of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Chiba, Japan.
Akira Asai2nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Yuichiro EguchiLiver Center, Saga University Hospital, Saga, Japan.
Jie LiDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Xiaozhong WangAffiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Jia LiDepartment of Gastroenterology and Hepatology, The Second People's Hospital of Tianjin, Tianjin, China.
Junping LiuDepartment of Infectious Diseases, Henan Provincial People's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Jing LiangDepartment of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin, China.
Carla Pui-Mei LamDepartment of Medicine, The University of Hong Kong, Hong Kong, China.
Rui HuangDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Qing YeDepartment of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin, China.
Hongying PanDepartment of Hepatology, Zhejiang Provincial People's Hospital Affiliated to Zhejiang University, Hangzhou, Zhejiang, China.
Jiajie ZhangDepartment of Hepatology, Zhejiang Provincial People's Hospital Affiliated to Zhejiang University, Hangzhou, Zhejiang, China.
Dachuan CaiDepartment of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qi WangCenter of liver diseases, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.
Daniel Q HuangDivision of Gastroenterology and Hepatology, National University Hospital, Singapore.
Grace WongDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Vincent Wai-Sun WongDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Junyi LiDepartment of Hepatology, The Third People's Hospital of Kunming City, Kunming, Yunnan, China.
Son DoDigestive Health Associates of Texas, Dallas, TX, USA.
Norihiro FurusyoTaihaku Avenue Clinic, Fukuoka, Japan.
Makoto NakamutaDepartment of Gastroenterology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Hideyuki NomuraDepartment of Internal Medicine, Haradoi Hospital, Fukuoka, Japan.
Eiji KajiwaraHepatology Clinic, Kajiwara Clinic, Kitakyushu, Japan.
Eileen L YoonDepartment of Internal Medicine, Hanyang University, College of Medicine, Seoul, Korea.
Sang Bong AhnDepartment of Internal Medicine, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, Korea.
Koichi AzumaDepartment of Medicine, Kyushu Central Hospital, Fukuoka, Japan.
Kazufumi DohmenDepartment of Internal Medicine, Chihaya Hospital, Fukuoka, Japan.
Jihyun AnDepartment of Internal Medicine, Hanyang University, College of Medicine, Guri Hospital, Guri, Korea.
Do Seon SongDivision of Hepatology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
Hyun Chin ChoDepartments of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.
Akira KawanoDepartment of Medicine, Kitakyushu Municipal Medical Center, Fukuoka, Japan.
Toshimasa KoyanagiDepartment of Medicine, Fukuoka City Hospital, Fukuoka, Japan.
Aritsune OohoDepartment of Hepatology, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
Takeaki SatohCenter for Liver Disease, National Hospital Organization Kokura Medical Center, Kitakyushu, Japan.
Kazuhiro TakahashiDepartment of Medicine, Hamanomachi Hospital, Fukuoka, Japan.
Ming-Lun YehHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung.
Pei-Chien TsaiHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung.
Satoshi YasudaDepartment of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan.
Yunyu ZhaoDepartment of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yishan LiuDepartment of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Tomomi OkuboDivision of Gastoroentelorogy, Nippon Medcal School Chiba Hokusoh Hospital, Chiba, Japan.
Norio ItokawaDivision of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan.
Mi Jung JunDepartment of Gastroenterology, Good Gang-An Hospital, Busan, Korea.
Toru IshikawaDepartment of Gastroenterology, Saiseikai Niigata Hospital, Niigata, Japan.
Koichi TakaguchiDepartment of Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan.
Tomonori SenohDepartment of Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan.
Mingyuan ZhangDepartment of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China.
Changqing ZhaoShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Raluca Ioana AlecuGastroenterology & Hepatology Department, Clinic Fundeni Institute, Bucharest, Romania.
Wei Xuan TayGastroenterology & Hepatology, Changi General Hospital, Singhealth, Singapore.
Pooja DevanGastroenterology & Hepatology, Changi General Hospital, Singhealth, Singapore.
Joanne Kimiko LiuDivision of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA.
Ritsuzo KozukaDepartment of Hepatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Elena Vargas-AccarinoLiver Diseases Group, Vall d'Hebron Research Institute, Barcelona, Spain.
Ai-Thien DoDigestive Health Associates of Texas, Dallas, TX, USA.
Mayumi MaedaDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Wan-Long ChuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung.
Jee-Fu HuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung.
Chia-Yen DaiHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung.
Ramsey CheungDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Maria ButiLiver Diseases Group, Vall d'Hebron Research Institute, Barcelona, Spain.
Junqi NiuDepartment of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China.
Wen XieCenter of liver diseases, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.
Hong RenDepartment of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Seng Gee LimDivision of Gastroenterology and Hepatology, National University Hospital, Singapore.
Chao WuDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Man-Fung YuenDepartment of Medicine, The University of Hong Kong, Hong Kong, China.
Jia ShangDepartment of Infectious Diseases, Henan Provincial People's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Qiang ZhuDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan, Shandong, China.
Yoshiyuki UenoDepartment of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Yasuhito TanakaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Jun HayashiKyushu General Internal Medicine Center, Haradoi Hospital, Fukuoka, Japan.
Ming-Lung YuHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung.
Mindie H NguyenDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.ORCID https://orcid.org/0000-0002-6275-4989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: As practice patterns and hepatitis C virus (HCV) genotypes (GT) vary geographically, a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination goal. This study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs, focusing on GT3 and GT6. Methods: We analyzed the sustained virological response (SVR12) of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific, North America, and Europe between 07/01/2014-07/01/2021. Results: The mean age was 62±13 years, with 49.6% male. The demographic breakdown was 91.1% Asian (52.9% Japanese, 25.7% Chinese/Taiwanese, 5.4% Korean, 3.3% Malaysian, and 2.9% Vietnamese), 6.4% White, 1.3% Hispanic/Latino, and 1% Black/African-American. Additionally, 34.8% had cirrhosis, 8.6% had hepatocellular carcinoma (HCC), and 24.9% were treatment-experienced (20.7% with interferon, 4.3% with direct-acting antivirals). The largest group was GT1 (10,246 [64.6%]), followed by GT2 (3,686 [23.2%]), GT3 (1,151 [7.2%]), GT6 (457 [2.8%]), GT4 (47 [0.3%]), GT5 (1 [0.006%]), and untyped GTs (261 [1.6%]). The overall SVR12 was 96.9%, with rates over 95% for GT1/2/3/6 but 91.5% for GT4. SVR12 for GT3 was 95.1% overall, 98.2% for GT3a, and 94.0% for GT3b. SVR12 was 98.3% overall for GT6, lower for patients with cirrhosis and treatment-experienced (TE) (93.8%) but ≥97.5% for treatment-naive patients regardless of cirrhosis status. On multivariable analysis, advanced age, prior treatment failure, cirrhosis, active HCC, and GT3/4 were independent predictors of lower SVR12, while being Asian was a significant predictor of achieving SVR12. Conclusions: In this diverse multinational real-world cohort of patients with various GTs, the overall cure rate was 96.9%, despite large numbers of patients with cirrhosis, HCC, TE, and GT3/6. SVR12 for GT3/6 with cirrhosis and TE was lower but still excellent (>91%).

Indexed as

DAAGenotypeHepatitis C virusHepatocellular carcinomaLiver cirrhosisREAL-C

Identifiers

PMID38993510
PMCPMC11233980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.