Metronidazole-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome With Parvovirus B19 Reactivation: A Pediatric Case.

Bahaeddine Dridi, Myriam Agrebi, Dhouha Sahnoun, Chaker Ben Salem

Abstract readCase Reports

In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

DRESS Syndrome Mimicking Postoperative Cholestasis: A Case Report.Clinical medicine insights. Case reports · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bahaeddine DridiPharmacology, Pharmacovigilance Center of Sousse, Faculty of Medicine of Sousse, University of Sousse, Sousse, TUN.

Myriam AgrebiPharmacology, Pharmacovigilance Center of Sousse, Faculty of Medicine of Sousse, University of Sousse, Sousse, TUN.

Dhouha SahnounPharmacology, Pharmacovigilance Center of Sousse, Faculty of Medicine of Sousse, University of Sousse, Sousse, TUN.

Chaker Ben SalemPharmacology, Pharmacovigilance Center of Sousse, Faculty of Medicine of Sousse, University of Sousse, Sousse, TUN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe and rare syndrome that causes life-threatening organ dysfunctions. Here, we present the case of a 10-year-old child who developed a pruritic erythematous eruption, fever, facial edema, and lymphadenopathy seven days after receiving intravenous metronidazole (20 mg/kg/day), vancomycin (50 mg/kg/day), and cefotaxime (200 mg/kg/day). Laboratory tests showed eosinophilia and liver damage as well as positive parvovirus B19 IgM and IgG indicating viral reactivation. Vancomycin was initially discontinued and later reintroduced with no ill effects. The patient was managed with topical corticosteroid emollients and cetirizine and improved within seven days of metronidazole withdrawal. Treatment with cefotaxime was continued and showed no adverse effects.

Indexed as

dress and virusesdress syndromedrug reaction with eosinophilia and systemic symptomsmetronidazole side effectsparvovirus b-19pediatricspharmacologypharmaco-vigilance

Identifiers

PMID38993456

DOI10.7759/cureus.62125

PMCPMC11238016

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