ArticleFrontiers in psychiatry2024
Relationship between serum inflammatory cytokines and suicide risk in patients with major depressive disorder.
Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Inflammatory Biomarkers in Acute Suicidal Behaviors.International journal of molecular sciences · 2026Review
- Serum inflammatory cytokines in the progression of depression.Frontiers in immunology · 2026Review
- Inflammatory models of depression in rodents and humans.Frontiers in psychiatry · 2026Review
- Bipolar and major depressive disorders: associations with serum zonulin levels and rs2070937 polymorphism.BMC psychiatry · 2025Article
- Epigenetics and immunology: Under-recognized aspects of suicidality.World journal of psychiatry · 2025Review
- Inflammatory markers and suicidal behavior: A comprehensive review of emerging evidence.Annals of general psychiatry · 2025Review
- Independent and interactive associations of inflammation, vascular homeostasis markers, and childhood trauma with suicide attempt history.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Association between body roundness index and suicidal ideation in U.S. adults: A cross-sectional study.Preventive medicine reports · 2025Article
- Association between interleukin-27 and suicidal ideation: a Mendelian randomization analysis and peripheral blood experimental study.Frontiers in psychiatry · 2025Article
- Advances in the assessment and study of suicide in late-life depression.Frontiers in psychiatry · 2025Review
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Authors and funding
3 authors.
Funding
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Abstract
Background: Studies have shown that increased inflammatory cytokines are associated with suicide risk, but the relationship between suicide risk and inflammatory cytokines is not clear. This study aimed to investigate the relationship between specific inflammatory markers and suicide risk in patients with MDD. Methods: This is a cross-sectional study. Firstly, we measured and compared psychological characteristics and 10 peripheral inflammatory cytokines in 130 MDD patients and 130 healthy controls(HC). Secondly, MDD patients were divided into 4 groups according to the severity of suicide risk for comparison between groups. Finally, multiple linear regression analysis was used to explore the predictors of suicide risk. Results: We found that the group with higher suicide risk had higher levels of IL-6, CRP, TNF-α, CXCL-2, and IFN-γ, and lower levels of IL-2 and IL-8 (all p<0.01). However, we found no difference in CRP between MIS and LS groups (p=0.337). Regression models were well-fitted. IL-2,IL-8 negatively predicted suicide risk (all p<0.05),IL-6,CRP,TNF-α,CXCL-2, and IFN-γ can positively predict the risk of suicide (all p<0.05). Limitations: This study employed a self-assessment scale. Conclusions: The higher the levels of IL-6, CRP, TNF-α, CXCL-2, and IFN-γ and the lower the levels of IL-2 and IL-8 of MDD patients, the higher the risk of suicide.
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