Evidence map›Paper›PMID 38993244›Full record

ArticleWorld journal of oncology2024

Association of Definitive Radiotherapy for Esophageal Cancer and the Incidence of Secondary Head and Neck Cancers: A SEER Population-Based Study.

Qian Qian Guo, Shi Zhou Ma, De Yao Zhao, Narasimha M Beeraka, Hao Gu, Yu Fei Zheng, Rui Wen Zhao, Si Ting Li, Vladimir N Nikolenko, Kirill V Bulygin and 3 more

Abstract read
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In one paragraph

Article in World journal of oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qian Qian GuoDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Shi Zhou MaDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
De Yao ZhaoDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Narasimha M BeerakaRaghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapuramu, Chiyyedu, Andhra Pradesh 515721, India.
Hao GuDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Yu Fei ZhengDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Rui Wen ZhaoDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Si Ting LiDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Vladimir N NikolenkoDepartment of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russian Federation.
Kirill V BulyginDepartment of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russian Federation.
Basappa BasappaLaboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Mysore, Karnataka 570006, India.
Rui Tai FanDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Jun Qi LiuDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Impact of radiotherapy (RT) for esophageal cancer (EC) patients on the development of secondary head and neck cancer (SHNC) remains equivocal. The objective of this study was to investigate the link between definitive RT used for EC treatment and subsequent SHNC. Methods: This study was conducted using the Surveillance, Epidemiology, and End Results (SEER) database to collect the data of primary EC patients. Fine-Gray competing risk regression and standardized incidence ratio (SIR) and propensity score matching (PSM) method were used to match SHNC patients with only primary head and neck cancer (HNC) patients. Overall survival (OS) rates were applied by Kaplan-Meier analysis. Results: In total, 14,158 EC patients from the SEER database were included, of which 9,239 patients (65.3%) received RT and 4,919 patients (34.7%) received no radiation therapy (NRT). After a 12-month latency period, 110 patients (1.2%) in the RT group and 36 patients (0.7%) in the NRT group experienced the development of SHNC. In individuals with primary EC, there was an increased incidence of SHNC compared to the general US population (SIR = 5.95, 95% confidence interval (CI): 5.15 - 6.84). Specifically, the SIR for SHNC was 8.04 (95% CI: 6.78 - 9.47) in the RT group and 3.51 (95% CI: 2.64 - 4.58) in the NRT group. Patients who developed SHNC after RT exhibited significantly lower OS compared to those after NRT. Following PSM, the OS of patients who developed SHNC after RT remained significantly lower than that of matched patients with only primary HNC. Conclusion: An association was discovered between RT for EC and increased long-term risk of SHNC. This work enables radiation oncologists to implement mitigation strategies to reduce the long-term risk of SHNC in patients who have received RT following primary EC.

Indexed as

Esophageal cancerRadiation therapySecondary head and neck cancerSEER database

Identifiers

PMID38993244
PMCPMC11236375

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