Evidence map›Paper›PMID 38993198›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2024

Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder.

Jinjing Hu, Jia Fu, Yuxin Cai, Shuping Chen, Mengjian Qu, Lisha Zhang, Weichao Fan, Ziyi Wang, Qing Zeng, Jihua Zou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinjing Hu *Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Jia Fu *Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Yuxin Cai *Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Shuping ChenDepartment of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Mengjian QuDepartment of Rehabilitation, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Lisha ZhangFaculty of Health and Social Sciences, Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Weichao FanDepartment of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Ziyi WangThe First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Qing ZengDepartment of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Jihua ZouDepartment of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurological pain (NP) is always accompanied by symptoms of depression, which seriously affects physical and mental health. In this study, we identified the common hub genes (Co-hub genes) and related immune cells of NP and major depressive disorder (MDD) to determine whether they have common pathological and molecular mechanisms. NP and MDD expression data was downloaded from the Gene Expression Omnibus (GEO) database. Common differentially expressed genes (Co-DEGs) for NP and MDD were extracted and the hub genes and hub nodes were mined. Co-DEGs, hub genes, and hub nodes were analyzed for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. Finally, the hub nodes, and genes were analyzed to obtain Co-hub genes. We plotted Receiver operating characteristic (ROC) curves to evaluate the diagnostic impact of the Co-hub genes on MDD and NP. We also identified the immune-infiltrating cell component by ssGSEA and analyzed the relationship. For the GO and KEGG enrichment analyses, 93 Co-DEGs were associated with biological processes (BP), such as fibrinolysis, cell composition (CC), such as tertiary granules, and pathways, such as complement, and coagulation cascades. A differential gene expression analysis revealed significant differences between the Co-hub genes ANGPT2, MMP9, PLAU, and TIMP2. There was some accuracy in the diagnosis of NP based on the expression of ANGPT2 and MMP9. Analysis of differences in the immune cell components indicated an abundance of activated dendritic cells, effector memory CD8

Indexed as

Computational BiologyMajor Depressive DisorderSystems BiologyDatabases, GeneticGene Expression ProfilingGene OntologyGene Regulatory NetworksHumansNeuralgiaProtein Interaction Mapsbioinformaticsgene expression omnibus (GEO)major depressive disorder (MDD)neurological painreceiver operating characteristic (ROC)

Identifiers

PMID38993198
PMCPMC11236560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.