Evidence map›Paper›PMID 38992996›Full record

ArticleAdvanced healthcare materials2024

Biofabrication and Monitoring of a 3D Printed Skin Model for Melanoma.

Paula Vázquez-Aristizabal, Malou Henriksen-Lacey, Clara García-Astrain, Dorleta Jimenez de Aberasturi, Judith Langer, Claudia Epelde, Lucio Litti, Luis M Liz-Marzán, Ander Izeta

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  13. High-YieldACS nano · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paula Vázquez-AristizabalStem Cells and Aging Group, Biogipuzkoa Health Research Institute, Paseo Dr. Begiristain s/n, Donostia-San Sebastián, 20014, Spain.ORCID 0000-0002-0086-690X
Malou Henriksen-LaceyCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián, 20014, Spain.ORCID 0000-0003-3544-5846
Clara García-AstrainCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián, 20014, Spain.ORCID 0000-0002-4231-7335
Dorleta Jimenez de AberasturiCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián, 20014, Spain.ORCID 0000-0001-5009-3557
Judith LangerCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián, 20014, Spain.
Claudia EpeldeObstetrics and Gynaecology Service, Donostia University Hospital, Paseo Dr. Begiristain s/n, Donostia-San Sebastián, 20014, Spain.
Lucio LittiDepartment of Chemical Sciences, University of Padova, Via Marzolo, 1, Padova, 35131, Italy.
Luis M Liz-MarzánCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián, 20014, Spain.ORCID 0000-0002-6647-1353
Ander IzetaStem Cells and Aging Group, Biogipuzkoa Health Research Institute, Paseo Dr. Begiristain s/n, Donostia-San Sebastián, 20014, Spain.ORCID 0000-0003-1879-7401

Funding

Agencia Estatal de Investigación MDM-2017-0720Diputación Foral de Gipuzkoa N/AEkonomiaren Garapen eta Lehiakortasun Saila, Eusko Jaurlaritza KK-2019/00006Ekonomiaren Garapen eta Lehiakortasun Saila, Eusko Jaurlaritza KK-2019/00093Ekonomiaren Garapen eta Lehiakortasun Saila, Eusko Jaurlaritza KK-2020/00010European Research Council ERC-AdG-2017#787510European UnionInstituto de Salud Carlos III PI22/01247Instituto de Salud Carlos III PT23/00142Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España IJC2019-040827-IOsasun Saila, Eusko Jaurlaritzako 2020111004Osasun Saila, Eusko Jaurlaritzako 20BU206
6 · The paper itself

Abstract

There is an unmet need for in vitro cancer models that emulate the complexity of human tissues. 3D-printed solid tumor micromodels based on decellularized extracellular matrices (dECMs) recreate the biomolecule-rich matrix of native tissue. Herein a 3D in vitro metastatic melanoma model that is amenable for drug screening purposes and recapitulates features of both the tumor and the skin microenvironment is described. Epidermal, basement membrane, and dermal biocompatible inks are prepared by means of combined chemical, mechanical, and enzymatic processes. Bioink printability is confirmed by rheological assessment and bioprinting, and bioinks are subsequently combined with melanoma cells and dermal fibroblasts to build complex 3D melanoma models. Cells are tracked by confocal microscopy and surface-enhanced Raman spectroscopy (SERS) mapping. Printed dECMs and cell tracking allow modeling of the initial steps of metastatic disease, and may be used to better understand melanoma cell behavior and response to drugs.

Indexed as

MelanomaPrinting, Three-DimensionalBioprintingCell Line, TumorExtracellular MatrixFibroblastsHumansInkModels, BiologicalSkinSkin NeoplasmsTissue EngineeringTissue Scaffolds3D bioprintingdECMmelanomametastasisSERS

Identifiers

PMID38992996
PMCPMC12344628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.