Evidence map›Paper›PMID 38992924›Full record

ArticleAnatomy & cell biology2024

Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model.

Fatimo Ajoke Sulaimon, Ruqayyah Yetunde Ibiyeye, Aminu Imam, Aboyeji Lukuman Oyewole, Abubakar Lekan Imam, Monsur Shehu, Sikiru Abayomi Biliaminu, Risikat Eniola Kadir, Gabriel Olaiya Omotoso, Moyosore Salihu Ajao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anatomy & cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fatimo Ajoke SulaimonDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0002-9594-608X
Ruqayyah Yetunde IbiyeyeDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Kwara State University, Malete, Nigeria.ORCID https://orcid.org/0000-0002-0628-1507
Aminu ImamDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0003-2371-3065
Aboyeji Lukuman OyewoleDepartment of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0001-6777-4201
Abubakar Lekan ImamDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0003-2076-1109
Monsur ShehuDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0002-2955-7668
Sikiru Abayomi BiliaminuDepartment of Chemical Pathology, Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0003-3159-7551
Risikat Eniola KadirDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0002-0097-4783
Gabriel Olaiya OmotosoDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0001-7727-6943
Moyosore Salihu AjaoDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.ORCID https://orcid.org/0000-0002-9074-1405

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) affects about 8.5 million individuals worldwide. Oxidative and inflammatory cascades are implicated in the neurological sequels, that are mostly unresolved in PD treatments. However, proper nutrition offers one of the most effective and least costly ways to decrease the burden of many diseases and their associated risk factors. Moreover, prevention may be the best response to the progressive nature of PD, thus, the therapeutic novelty of honey and levodopa may be prospective. This study aimed to investigate the neuroprotective role of honey and levodopa against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced oxidative stress. Fifty-four adult male Swiss mice were divided into control and PD model groups of 27 mice. Each third of the control mice either received phosphate buffered saline, honey, or levodopa for 21 days. However, each third of the PD models was either pretreated with honey and levodopa or not pretreated. Behavioral studies and euthanasia were conducted 2 and 8 days after MPTP administration respectively. The result showed that there were significantly (

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineHoneyLevodopaNrf2Parkinson disease

Identifiers

PMID38992924
PMCPMC11424567

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.