Evidence map›Paper›PMID 38992756›Full record

ArticleEnvironmental research2024

Associations of serum persistent organic pollutant concentrations with incident diabetes in midlife women: The Study of Women's Health Across the Nation Multi-Pollutant Study.

Amelia Grant-Alfieri, William H Herman, Deborah J Watkins, Stuart Batterman, Carrie Karvonen-Gutierrez, Sung Kyun Park

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Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amelia Grant-AlfieriDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
William H HermanDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.
Deborah J WatkinsDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Stuart BattermanDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Carrie Karvonen-GutierrezDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Sung Kyun ParkDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. Electronic address: sungkyun@umich.edu.

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old AgeU19AG063720 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHERRI-ANN M BURNETT-BOWIE, Maria Mori Brooks · 2020 to 2026
$61.3M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
University of Michigan ERC-supplement (TRT)T42OH008455 · OH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEITZEL, RICHARD L · 2005 to 2025
$32.3M
SWAN Repository IVU01AG017719 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 2000 to 2020
$25.0M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
NCRR NIH HHS UL1 RR024131NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NIA NIH HHS U01 AG017719NIA NIH HHS U19 AG063720NIDDK NIH HHS P30 DK020572NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES026578NIEHS NIH HHS R01 ES026964NIEHS NIH HHS R01 ES035087NIEHS NIH HHS T32 ES007062NINR NIH HHS U01 NR004061NIOSH CDC HHS T42 OH008455
6 · The paper itself

Abstract

backgroundOrganochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) that can negatively impact metabolic health through pathways including endocrine disruption. Few studies have evaluated diabetes risk associated with PBDEs. Little is known about the joint effect of exposure to POP mixtures on diabetes risk.

objectivesWe investigated the relationship between POPs, individually and as mixtures, and diabetes development over 18 years (1999-2016) in midlife women.

methodsWe measured lipid-standardized serum concentrations of 34 PCBs, 19 OCPs, and 14 PBDEs in 1040 midlife women aged 45-56 years from the Study of Women's Health Across the Nation. We tested the association between POPs measured in 1999/2000 and incident diabetes using Cox proportional hazards models. We evaluated diabetes risk associated with the overall POP mixture using Quantile-Based G-Computation (QBGC).

resultsFor most mixture components, single pollutant and mixtures analyses indicated null associations with diabetes risk, however results were inconsistent. After adjustment, hazard ratios (HRs) of developing diabetes (95% CI) associated with upper exposure tertiles (T2/T3) compared with the first tertile (T1), were 1.7 (1.0, 2.8) at T2 and 1.5 (0.84, 2.7) at T3 for hexachlorobenzene and 1.9 (1.1, 3.3) at T2 and 1.6 (0.88, 2.9) at T3 for PCB 123. A doubling of PBDE 47 was associated with 1.11 (1.00, 1.24) times the risk of T2D. QBGC identified no association for the overall joint effect of the POP mixture on diabetes (HR = 1.04 [0.53, 2.07]).

conclusionExposure to a mixture of PCBs, OCPs, and PBDEs was not associated with incident diabetes in midlife U.S. women, although some individual POPs demonstrated significant yet inconsistent associations with diabetes. Non-linear and non-monotonic dose-response dynamics deserve further exploration. More research is needed on the diabetogenic effects of PBDEs.

Indexed as

Diabetes MellitusHalogenated Diphenyl EthersHydrocarbons, ChlorinatedPersistent Organic PollutantsPolychlorinated BiphenylsEnvironmental ExposureEnvironmental PollutantsFemaleHumansIncidenceMiddle AgedPesticidesUnited StatesWomen's HealthEnvironmental PollutantsHalogenated Diphenyl EthersHydrocarbons, ChlorinatedPersistent Organic PollutantsPesticidesPolychlorinated BiphenylsDiabetesPBDEsPCBsPersistent organic pollutantsPesticidesWomen

Identifiers

PMID38992756
PMCPMC11656409

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.