Evidence map›Paper›PMID 38992754›Full record

ArticleEnvironmental research2024

Organophosphate ester flame retardant chemicals and maternal depression during pregnancy.

Ixel Hernandez-Castro, Sandrah P Eckel, Caitlin G Howe, Max T Aung, Kurunthachalam Kannan, Morgan Robinson, Helen B Foley, Tingyu Yang, Mario J Vigil, Xinci Chen and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ixel Hernandez-CastroDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Epidemiology and Population Health, Stanford Medicine, Stanford, CA, USA.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Caitlin G HoweDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, New Hampshire, USA.
Max T AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kurunthachalam KannanWadsworth Center, New York State Department of Health, Albany, NY, USA.
Morgan RobinsonWadsworth Center, New York State Department of Health, Albany, NY, USA.
Helen B FoleyDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tingyu YangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Mario J VigilDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xinci ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brendan GrubbsDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Laila Al-MarayatiDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Claudia M Toledo-CorralDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Health Sciences, California State University Northridge, Northridge, CA, USA.
Rima HabreDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Genevieve F DuntonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Shohreh F FarzanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Santiago MoralesDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Carrie V BretonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Theresa M BastainDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: bastain@usc.edu.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR)U2CES026542 · NIEHS · WADSWORTH CENTER · PI KANNAN, KURUNTHACHALAM, PARSONS, PATRICK J. · 2015 to 2025
$15.6M
Project 3: Maternal Exposure to Environmental Hazards and Psychosocial Stressors and Postpartum Allostatic LoadP50MD015705 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HABRE, RIMA · 2020 to 2024
$8.1M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JOHNSTON, JILL E · 2015 to 2019
$3.7M
Prenatal Metal Mixtures, Fetal Growth, and the Role of MicroRNAsR00ES030400 · NIEHS · DARTMOUTH COLLEGE · PI HOWE, CAITLIN GRACE · 2020 to 2022
$726k
NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P50 ES026086NIEHS NIH HHS R00 ES030400NIEHS NIH HHS U2C ES026542NIH HHS UH3 OD023287NIMHD NIH HHS P50 MD015705
6 · The paper itself

Abstract

backgroundDepression substantially contributes to pregnancy-related morbidity, and pregnancy is increasingly recognized as a vulnerable window for exposure effects on maternal mental health. Exposures to organophosphate esters (OPEs) are ubiquitous and may have neurotoxic effects; however, their impacts on prenatal depression remain unknown. We evaluated associations of third trimester OPE metabolites on maternal depressive symptoms during pregnancy.

methodsThis study included 422 participants in the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) cohort, a prospective pregnancy cohort of primarily low-income and Hispanic participants residing in Los Angeles, California. We measured concentrations of nine OPEs in third trimester spot urine samples (mean gestational age = 31.5 ± 2.0 weeks). Using the Center for Epidemiologic Studies-Depression (CES-D) scale, we classified participants as having probable depression during pregnancy (N = 137) or not (N = 285) if one or more CES-D scores administered at each trimester met the suggested cutoff score for clinically significant depressive symptoms (≥16). We estimated associations of prenatal OPE metabolite concentrations in tertiles and risk of prenatal depression using modified Log-Poisson regression. We examined associations of the OPE mixture on depression during pregnancy using Bayesian kernel machine regression (BKMR).

resultsParticipants with the highest tertiles of DPHP and BDCIPP exposure had a 67% (95% CI: 22%, 128%) and 47% (95% CI: 4%, 108%) increased risk of maternal depressive symptoms during pregnancy, respectively. No associations between other OPE metabolites and maternal depression symptoms were observed. In mixture analyses, we observed a positive and linear association between higher exposure to the OPE metabolite mixture and odds of prenatal maternal depression, primarily driven by DPHP.

conclusionsOur findings provide new evidence of associations between frequently detected OPE metabolites on maternal depression symptoms during pregnancy. Results could inform future intervention efforts aimed at reducing perinatal maternal depression.

Indexed as

DepressionFlame RetardantsOrganophosphatesAdultEnvironmental PollutantsEstersFemaleHumansLos AngelesMaternal ExposurePregnancyPregnancy ComplicationsPregnancy Trimester, ThirdProspective StudiesYoung AdultEnvironmental PollutantsEstersFlame RetardantsOrganophosphatesMaternal depressionMixtures analysisOrganophosphate esters

Identifiers

PMID38992754
PMCPMC11365806

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.