Evidence map›Paper›PMID 38992695›Full record

ReviewJournal of biomedical science2024

Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials.

Yi-Fan Chen, Frank Luh, Yuan-Soon Ho, Yun Yen

Abstract readReview
In one paragraph

Review in Journal of biomedical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  13. [Advances in stem cell and exosome-based therapies for dry eye disease].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Exosome-mediated siRNA delivery in cancer: Loading strategies, targeting approaches, and therapeutic outcomes.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  19. Article
  20. Article

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi-Fan ChenInternational Master Program in Translation Science, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 23564, Taiwan.
Frank LuhSino-American Cancer Foundation, Covina, CA, 91722, USA.
Yuan-Soon HoInstitute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, 406040, Taiwan. hoyuansn@mail.cmu.edu.tw.
Yun YenTMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan. yyen@tmu.edu.tw.ORCID http://orcid.org/0000-0003-0815-412X

Funding

Ministry of Health and Welfare MOHW112-TDU-B-222-014013Ministry of Health and Welfare MOHW113-TDU-B-222-134013Ministry of Science and Technology MOST 110-2320-B-038-070National Science and Technology Council (NSTC 112-2320-B-038-020
6 · The paper itself

Abstract

Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.

Indexed as

ExosomesNeoplasmsClinical Trials as TopicDrug Delivery SystemsHumansCancer diagnosisCancer therapyExosomesiRNA

Identifiers

PMID38992695
PMCPMC11238361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.