Evidence map›Paper›PMID 38992342›Full record

ArticleJournal of thrombosis and haemostasis : JTH2024

Utility of thromboelastography with platelet mapping for monitoring platelet transfusion in qualitative platelet disorders.

Robert H Lee, Tanvi Rudran, Wolfgang Bergmeier

Abstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Robert H LeeDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA; Blood Research Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address: https://twitter.com/RobertHLee8.
Tanvi RudranDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA.
Wolfgang BergmeierDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA; Blood Research Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address: bergmeie@email.unc.edu.

Funding

Small GTPases in the biology of platelets and megakaryocytesR35HL144976 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BERGMEIER, WOLFGANG · 2019 to 2025
$5.4M
NHLBI NIH HHS R35 HL144976
6 · The paper itself

Abstract

backgroundPatients with pathogenic variants in RASGRP2 (inherited platelet disorder (IPD)-18) exhibit normal platelet counts but impaired platelet aggregation and α

objectiveWe here studied the usefulness of thromboelastography with platelet mapping (TEG-PM) for ex vivo monitoring of the hemostatic potential in Rasgrp2

methodsWhole blood (WB) samples from WT and Rasgrp2

resultsRasgrp2

conclusionThis proof-of-concept study supports the use of TEG-PM to monitor platelet transfusion ratios and hemostatic potential in IPD-18 and potentially other platelet disorders.

Indexed as

Blood Platelet DisordersBlood PlateletsDisease Models, AnimalHemostasisMice, KnockoutPlatelet TransfusionThrombelastographyAnimalsBlood CoagulationGuanine Nucleotide Exchange FactorsHemorrhageMiceMice, Inbred C57BLPlatelet AggregationPlatelet Function TestsPredictive Value of TestsGuanine Nucleotide Exchange FactorsRasgrp2 protein, mouseblood platelet disordersblood plateletsplatelet transfusionthromboelastography

Identifiers

PMID38992342
PMCPMC11416304

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.