Evidence map›Paper›PMID 38992336›Full record

ArticleGeroScience2025

Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition.

Andreas F Kolb, Claus Mayer, Alina Zitskaja, Linda Petrie, Khulod Hasaballah, Claire Warren, Ailsa Carlisle, Simon Lillico, Bruce Whitelaw

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andreas F KolbNutrition, Obesity and Disease Research Theme, Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland. a.kolb@abdn.ac.uk.ORCID 0000-0001-9056-5504
Claus MayerBiomathematics and Statistics Scotland (BioSS), University of Aberdeen, Aberdeen, AB25 2ZD, Scotland.
Alina ZitskajaNutrition, Obesity and Disease Research Theme, Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland.
Linda PetrieNutrition, Obesity and Disease Research Theme, Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland.
Khulod HasaballahNutrition, Obesity and Disease Research Theme, Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland.
Claire WarrenRoslin Institute, University of Edinburgh, Edinburgh, Scotland.
Ailsa CarlisleRoslin Institute, University of Edinburgh, Edinburgh, Scotland.
Simon LillicoRoslin Institute, University of Edinburgh, Edinburgh, Scotland.
Bruce WhitelawRoslin Institute, University of Edinburgh, Edinburgh, Scotland.

Funding

Biotechnology and Biological Sciences Research Council #12599Biotechnology and Biological Sciences Research Council CASE studentship BB/J012343/1Genomia Trust protein expression in protein poor milkRural and Environment Science and Analytical Services Division Transition FundingSaudi Arabian Cultural Bureau PhD project grant
6 · The paper itself

Abstract

Early nutrition has significant effects on physiological outcomes during adult life. We have analysed the effect of maternal α-casein (CSN1S1) deficiency on the physiological fate of dams and their offspring. α-casein deficiency reduces maternal milk protein concentration by more than 50% and attenuates the growth of pups to 27% (p < 0.001) of controls at the point of weaning. This is associated with a permanent reduction in adult body weight (- 31% at 25 weeks). Offspring nursed by α-casein deficient dams showed a significantly increased lifespan (+ 20%, χ

Indexed as

Body CompositionCaseinsLongevityAnimalsBody WeightFemaleLiverMaleMicePregnancyCaseinsGrowthPerinatal nutritionProgramming

Identifiers

PMID38992336
PMCPMC12181513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.