Evidence map›Paper›PMID 38992316›Full record

ArticlePathologie (Heidelberg, Germany)2024

[Quantification of Ki-67 in PitNET (pituitary neuroendocrine tumors)/adenomas].

Judith Klein, Kai Saeger, Wolfgang Saeger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathologie (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Judith KleinInstitut für Neuropathologie der Universität Hamburg, UKE, Martinistraße 52, 20246, Hamburg, Deutschland.
Kai SaegerInstitut für Neuropathologie der Universität Hamburg, UKE, Martinistraße 52, 20246, Hamburg, Deutschland.
Wolfgang SaegerInstitut für Neuropathologie der Universität Hamburg, UKE, Martinistraße 52, 20246, Hamburg, Deutschland. w.saeger@uke.de.ORCID http://orcid.org/0000-0003-3340-8523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study is the first to compare the determination of the Ki-67 index in pituitary neuroendocrine tumors (PitNET)/pituitary adenomas by pathologists with a computerized method (Cognition MasterSuite from VMScope, Berlin, Germany). PitNET/pituitary adenomas often show a low proliferation index. Observer variability is high, especially when estimating in this low percentage range. A more reliable determination would be possible using the four-eyes principle, but this cannot be realized continuously; thus, digital image analysis is a promising solution. In the study, there was clear agreement between the Ki-67 estimate by two experienced pathologists and the determination with the aid of digital image analysis. The digital image analysis system is excellent for determining the proliferation rate of PitNET/pituitary adenomas and can therefore be used to determine the "third" and "fourth eye".

Indexed as

AdenomaKi-67 AntigenNeuroendocrine TumorsPituitary NeoplasmsAdultCell ProliferationFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedObserver VariationKi-67 AntigenDigital image analysisKi-67-indexPitNET/adenomaPituitary glandProliferation

Identifiers

PMID38992316
PMCPMC11343892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.