Evidence map›Paper›PMID 38992294›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Might photobiomodulation therapy interfere with the frequency of severe mucositis and oral candidiasis? A retrospective analysis in patients with head and neck carcinoma.

Rebeca Barros Nascimento, Bruna Portela Neri, Mylena Melo Moutinho, Tila Fortuna, Gabriela Botelho Martins, Manoela Carrera, Hayana Ramos Lima

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebeca Barros NascimentoFaculty of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.ORCID http://orcid.org/0000-0002-9360-9725
Bruna Portela NeriFaculty of Physiotherapy, Federal University of Bahia, Salvador, Bahia, Brazil.ORCID http://orcid.org/0000-0002-2639-4533
Mylena Melo MoutinhoFaculty of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.ORCID http://orcid.org/0000-0002-6266-6890
Tila FortunaInteractive Processes of Organs and Systems Post Graduation Program, Institute of Health Sciences, Salvador, Bahia, Brazil.ORCID http://orcid.org/0000-0002-9676-9185
Gabriela Botelho MartinsInteractive Processes of Organs and Systems Post Graduation Program, Institute of Health Sciences, Salvador, Bahia, Brazil.ORCID http://orcid.org/0000-0002-0917-4598
Manoela CarreraFaculty of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.ORCID http://orcid.org/0000-0002-3711-5835
Hayana Ramos LimaCenter of Health Sciences, Federal University of Southern Bahia, Teixeira de Freitas, Praça Joana Angélica, No. 250Zip Code: 45988-058, Bahia, Brazil. hayana.lima@ufsb.Edu.br.ORCID http://orcid.org/0000-0001-9227-7565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeConsidering the tumor in the oral cavity or the oropharynx and nasopharynx region might be an aggravating factor for oral mucositis (OM) manifestation, the present study aimed to evaluate whether the location of the tumor and the use of photobiomodulation therapy (PBMT) might affect the frequency of oral candidiasis (OC) during radiotherapy (RT) and/or chemotherapy (CT) treatments.

methodsThe medial records of seventy-four patients with head and neck cancer treated in a public service from 2016 to 2019 were evaluated. All these patients were submitted to RT in an accumulated dose of 48 to 70 Gy of radiation. Data about OM and OC were collected and presented according to the application of a therapeutic protocol with laser photobiomodulation (PBMT) to control oral mucositis, or not (No-PBM), and the location of tumor (head and neck or oral cavity). In the PBMT group patients, a low-power laser device composed of InGaAlP diode (maximum output power of 86.7 mW, active tip area of 0.1256 cm

resultsMucositis grades 1 and 2 were the most common among all patients, especially before the 12th radiotherapy session, regardless of the treatment with PBM (p > 0.05). Additionally, no difference in the grade of OM and OC was significantly observed when comparing the two laser therapy groups. OC was more frequent after the 12th radiotherapy session in all groups. Nonetheless, OM and OC had a different correlation regarding to tumor location (head and neck and oral cavity) being PBMT a positive therapy to delay OM. It was observed a positive and statistically significant correlation between tumors at oral cavity and OM, regardless PBMT (R = 0.84, p < 0.05 to PBMT and R = 0.13, p < 0.05 to No-PBM). Otherwise, OC was positively correlated to local metastasis in patients with oral tumors undergoing PBMT (R = 0.84, p < 0.05).

conclusionPatients with oral cavity tumor presented more OM, especially high grades, then patients with tumors in other regions of the head and neck, which seems to be related to the irradiation parameters of radiotherapy and/or with the limitation of conduction of PBMT in tumor areas. OM and OC were not changed by PBMT, although it helped to reduce the incidence of severe cases of OM.

Indexed as

Candidiasis, OralHead and Neck NeoplasmsLow-Level Light TherapyStomatitisAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesChemotherapyHead and neck cancerOral candidiasisOral mucositisPhotobiomodulation therapyRadiotherapy

Identifiers

PMID38992294

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.